17512-69-5

Basic information

• Product Name: Benzamide, 2-chloro-N-hydroxy-
• CAS NO: 17512-69-5
• Molecular Formula: C7H6ClNO2
• Molecular Weight: 171.583
• Mol File: 17512-69-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzamide, 2-chloro-N-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 2-chloro-N-hydroxy-(17512-69-5)
• EPA Substance Registry System: Benzamide, 2-chloro-N-hydroxy-(17512-69-5)

Safety Data

• Hazardous Substances Data: 17512-69-5(Hazardous Substances Data)

Upstream product

• 610-96-8 methyl chlorobenzoate 
• 7335-25-3 ethyl 2-chlorobenzoate 
• 118-91-2 ortho-chlorobenzoic acid 
• 3717-28-0 2-chloro benzaldehyde oxime 

Downstream Products

• 3320-83-0 o-chlorophenyl isocyanate 
• 2596-93-2 2-chloro-N-phenylformamide 
• 1394836-92-0 4-chloro-1-(2-chlorobenzoyl)benzo[c]isoxazol-3(1H)-one 
• 95-51-2 o-chloroaniline 

Relevant articles and documents

An efficient method for the preparation of hydroxamic acids

Reactions of acyl chlorides with hydroxylamine hydrochloride and NaHCO 3 generate the corresponding hydroxamic acid products in ethyl acetate and water at room temperature for 5 min. This is a simple and efficient method to synthesize a wide range of hydroxamic acids from carboxylic acids in excellent yield and high purity after simple post-treatment without chromatographic purification. In this process, the highlights are the simple separation of products and cheaply available reagents.

A convenient one-pot synthesis of aryl amines from aryl aldoximes mediated by Koser's reagent

A simple and convenient procedure has been developed for the synthesis of aromatic amine by a one-pot reaction of aromatic aldoxime with hypervalent iodine(III) reagent [hydroxy(tosyloxy)iodo]benzene (HTIB, Koser's reagent), in an alkaline medium. The aldoxime reacts with Koser's reagent to form an intermediate hydroxamic acid, which then undergoes Lossen type rearrangement to produce the desired amine. Several amines have been prepared which otherwise are difficult to prepare, by the reduction of corresponding nitro compounds. The scopes and limitations of this transformation have been discussed. ARKAT-USA, Inc.

Carbonyldiimidazole-mediated lossen rearrangement

[Chemical Equation Presented] Carbonyldiimidazole (CDI) was found to mediate the Lossen rearrangement of various hydroxamic acids to isocyanates. This process is experimentally simple and mild, with imidazole and CO 2 being the sole stoichiometric byproduct. Significant for large-scale application, the method avoids the use of hazardous reagents and thus represents a green alternative to standard processing conditions for the Curtius and Hofmann rearrangements.