17392-15-3

Basic information

• Product Name: 3(2H)-Benzofuranone, 2-hydroxy-
• Synonyms: 3(2H)-Benzofuranone, 2-hydroxy-;2-hydroxybenzofuran-3(2H)-one
• CAS NO: 17392-15-3
• Molecular Formula: C₈H₆O₃
• Molecular Weight: 150.13
• Mol File: 17392-15-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 108.5-110 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 327.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.456±0.06 g/cm3(Predicted)
• PKA: 10.38±0.20(Predicted)
• CAS DataBase Reference: 3(2H)-Benzofuranone, 2-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 3(2H)-Benzofuranone, 2-hydroxy-(17392-15-3)
• EPA Substance Registry System: 3(2H)-Benzofuranone, 2-hydroxy-(17392-15-3)

Safety Data

• Hazardous Substances Data: 17392-15-3(Hazardous Substances Data)

Upstream product

• 2491-36-3 2-(2-bromoacetyl)hydroxybenzene 
• 118-93-4 o-hydroxyacetophenone 
• 7647-01-0 hydrogenchloride 
• 60-29-7 diethyl ether 
• 13312-85-1 2-hydroxy-2-(2-hydroxyphenyl)acetonitrile 
• 90-02-8 salicylaldehyde 
• 271-89-6 1-benzofurane 

Downstream Products

• 57705-21-2 1-(2-hydroxylphenyl)-2-morpholinoethane-1,2-dione 

Relevant articles and documents

C-H bond cleavage-enabled aerobic ring-opening reaction of: In situ formed 2-aminobenzofuran-3(2 H)-ones

A C-H bond cleavage-enabled aerobic ring-opening reaction of 2-aminobenzofuran-3(2H)-ones formed in situ by hemiacetals with a variety of amines is reported. This simple one-pot reaction provides an alternative approach to obtain o-hydroxyaryl glyoxylamides in excellent yields of up to 97%. Alkylamines react with hemiacetals via a catalyst-free dehydration condensation to generate 2-aminobenzofuran-3(2H)-ones. The in situ formed semicyclic N,O-acetals undergo the same amine-initiated C-H bond hydroxylation in air under mild conditions to afford ring-opening products. Similarly, arylamines were investigated as substrates for a two-step tandem process involving a DPP-catalyzed condensation followed by a Et2NH-mediated C-H hydroxylation. Unlike the previously reported functionalization of N,O-acetals via a C-O or C-N cleavage, the aerobic oxidative C-H hydroxylation in this reaction, which is promoted by using stoichiometric amounts of alkylamines as both a Lewis base and a reductant at room temperature under atmospheric air, proceeds via α-carbonyl-stabilized carbanion intermediates from the C-H cleavage of N,O-acetals. This journal is

Logical design and synthesis of indole-2,3-diones and 2-hydroxy-3(2H)- benzofuranones via one-pot intramolecular cyclization

A novel and attractive protocol to synthesis indole-2,3-diones and 2-hydroxy-3(2H)-benzofuranones and via copper(II) oxide catalyzed intramolecular cyclization is described. This method possesses functional-group compatibility, easy workup procedure, shorter reaction time and high yields.