1735-91-7

Basic information

• Product Name: 2-NITRO-4-(TRIFLUOROMETHYL)PHENYLACETIC ACID
• Synonyms: RARECHEM AL BO 0474;2-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]ACETIC ACID;2-NITRO-4-(TRIFLUOROMETHYL)PHENYLACETIC ACID;(2-nitro-4-trifluorobenzyl)acetic acid;2-Nitro-4-(trifluoromethyl)phenylacetic acid 98%;2-Nitro-4-(trifluoromethyl)phenylaceticacid98%;2-Nitro-4-(trifluoromethyl)benzeneacetic acid;2-[2-nitro-4-(trifluoromethyl)phenyl]acetic acid (en)
• CAS NO: 1735-91-7
• Molecular Formula: C₉H₆F₃NO₄
• Molecular Weight: 249.14
• EINECS: 217-081-5
• Product Categories: blocks;Carboxes;NitroCompounds
• Mol File: 1735-91-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 144-146°C
• Boiling Point: 323.9 °C at 760 mmHg
• Flash Point: 149.7 °C
• Appearance: /
• Density: 1.535 g/cm³
• Vapor Pressure: 0.000105mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-NITRO-4-(TRIFLUOROMETHYL)PHENYLACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-NITRO-4-(TRIFLUOROMETHYL)PHENYLACETIC ACID(1735-91-7)
• EPA Substance Registry System: 2-NITRO-4-(TRIFLUOROMETHYL)PHENYLACETIC ACID(1735-91-7)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39-24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 1735-91-7(Hazardous Substances Data)

Usage

General Description

2-Nitro-4-(trifluoromethyl)phenylacetic acid is a chemical compound with the molecular formula C9H6F3NO4. It is a white to yellowish crystalline powder that is sparingly soluble in water. 2-NITRO-4-(TRIFLUOROMETHYL)PHENYLACETIC ACID is often used as an intermediate in the production of pharmaceuticals and agrochemicals. It is also used as a reagent in organic synthesis for the preparation of various compounds. Additionally, 2-Nitro-4-(trifluoromethyl)phenylacetic acid is known for its anti-inflammatory and painkilling properties, making it a valuable ingredient in certain medications. However, it should be handled with care due to its potential hazards and toxicity.

InChI:InChI=1/C9H6F3NO4/c10-9(11,12)6-2-1-5(3-8(14)15)7(4-6)13(16)17/h1-2,4H,3H2,(H,14,15)/p-1

Upstream product

• 7664-93-9 sulfuric acid 
• 32857-62-8 4-Trifluoromethylphenylacetic acid 
• 290825-52-4 dimethyl 2-(2-nitro-4-trifluoromethylphenyl)malonate 
• 120542-04-3 tert-butyl 2-nitro-4-trifluoromethyl-phenylacetate 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 98-56-6 4-chlorobenzotrifluoride 
• 13544-04-2 Ethyl 2-cyano-2-(2-nitro-4-(trifluoromethyl)phenyl)acetate 

Downstream Products

• 35318-52-6 2'-Nitro-4,4'-bis-(trifluormethyl)-α-phenylzimtsaeure 
• 38597-55-6 (E)-3-(3-Bromo-phenyl)-2-(2-nitro-4-trifluoromethyl-phenyl)-acrylic acid 
• 38635-63-1 (E)-3-(3,5-Bis-trifluoromethyl-phenyl)-2-(2-nitro-4-trifluoromethyl-phenyl)-acrylic acid 
• 38635-59-5 (E)-3-(3,5-Dichloro-phenyl)-2-(2-nitro-4-trifluoromethyl-phenyl)-acrylic acid 
• 35318-48-0 4-Chlor-2'-nitro-4'-trifluormethyl-α-phenylzimtsaeure 
• 35318-45-7 2'-Nitro-4'-trifluormethyl-α-phenylzimtsaeure 
• 38635-54-0 (E)-3-(2,4-Dichloro-phenyl)-2-(2-nitro-4-trifluoromethyl-phenyl)-acrylic acid 
• 35318-47-9 4-Brom-2'-nitro-4'-trifluormethyl-α-phenylzimtsaeure 
• 38635-53-9 (E)-3-(2,3-Dichloro-phenyl)-2-(2-nitro-4-trifluoromethyl-phenyl)-acrylic acid 
• 294673-65-7 ethyl 4-[2-nitro-4-(trifluoromethyl)phenyl]-3-oxobutanoate 
• 340216-48-0 2-[2-nitro-4-(trifluoromethyl)phenyl]acetohydrazide 
• 922711-88-4 C₉H₅ClF₃NO₃ 
• 1735-89-3 6-trifluoromethyl-2-indolinone 
• 951883-90-2 C₉H₆F₃NO₂ 

Relevant articles and documents

Substituted indolinones, their manufacture and their use as medicaments

The present invention relates to substituted indolinones of general formula wherein R1to R6and X are defined as in claim 1, the isomers and the salts thereof, in particular the physiologically acceptable salts thereof which have valuable pharmacological properties, especially an inhibitory effect on various receptor-tyrosine kinases, and cycline/CDK complexes as well as on the proliferation of endothelial cells and various tumor cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.

Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith

Method for the prevention or treatment of pruritis by administering to a patient an antipruritic compound, or pharmaceutically acceptable salt thereof, of the class arylacetamide, which is exemplified by compounds of the formulae I, II, IIA, III, IV and IVA having the structures: and in which R1-4, X, X4, X5, X7, X9, Y and Z are as described in the specification.