172331-68-9

Basic information

• Product Name: Dehydro Barnidipine
• Synonyms: Dehydro Barnidipine;Methyl 2,6-DiMethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid (3S)-1-(PhenylMethyl)-3-pyrrolidinyl Ester
• CAS NO: 172331-68-9
• Molecular Formula: C27H27N3O6
• Molecular Weight: 489.51978
• Product Categories: Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Aromatics, Chiral Reagents, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 172331-68-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Dehydro Barnidipine(CAS DataBase Reference)
• NIST Chemistry Reference: Dehydro Barnidipine(172331-68-9)
• EPA Substance Registry System: Dehydro Barnidipine(172331-68-9)

Safety Data

• Hazardous Substances Data: 172331-68-9(Hazardous Substances Data)

Usage

Uses

A metabolite of Barnidipine (B118700) in human plasma.

Upstream product

• 88712-56-5 1,4-dihydro-2,6-dimethyl-3-methoxycarbonyl-4-(3-nitrophenyl)-pyridine-5-carboxylic acid chloride 
• 104713-75-9 barnidipine 
• 76093-33-9 (R)-5-(methoxycarbonyl)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid 
• 74936-72-4 5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid 
• 75130-24-4 2,6-dimethyl-4-(3-nitrophenyl)-5-methoxycarbonyl-1,4-dihydropyridine-3-carboxylic acid 2-cyanoethyl ester 
• 102993-38-4 2-cyanoethyl 2-(3-nitrobenzylidene)-3-oxobutanoate 
• 99-61-6 3-nitro-benzaldehyde 
• 104757-53-1 [14C]-Barnidipine hydrochloride 

Relevant articles and documents

Different photodegradation behavior of barnidipine under natural and forced irradiation

An in depth study on photodegradation of barnidipine, a new 1,4-dihydropyridine antihypertensive drug, was performed by exposing the drug to natural and stressing light irradiation. A different degradation process and distribution of photoproducts under different light sources and irradiation power were demonstrated. Degradation kinetics, reactive excited states involved, transient species and photoproducts generated were investigated. Exposure of barnidipine to forced irradiation caused a complex degradation pathway. Kinetics of this process was studied by HPLC and spectrophotometry, demonstrating the formation of several by-products. In contrast, the drug, under direct or indirect sunlight, underwent oxidation generating the pyridine derivative as the main photodegradation product, according to most of the drug congeners. HPLC and derivative spectrophotometric methods were defined for the simultaneous assay of the drug and its pyridinic by-product, useful as a routine control method of the drug formulations.

Dihydropyridine compound dehydrogenation aromatization method and in use in the drug detection (by machine translation)

Relates to dihydropyridine compound dehydrogenation aromatization method and in use in the drug detection, compounds such as nifedipine, amlodipine, Cini horizontal, Lacidipine, felodipine, NIKA of amlodipine, nitrendipine, nimodipine and BANI to equal, the method in acidic aqueous solution in the presence of a nickel-containing catalyst in the oxidation reaction of the then purified to realize. The method can be used for preparing this kind of drug detection and quality monitoring of the impurity reference substance, also can be used for quality detection process is used in the instrument of the instrument such as the dissolution of the design reference, drug synthesis process and the design of the manufacturing process of the preparation of the reference, in order to avoid impurities introduced by the process channels, in addition can also be dihydropyridine compound of related synthetic process route provides design provides a reference. The reaction can be in the acidic aqueous solution, to a suitable oxidant (such as air) as the oxidizing agent, in the presence of nickel, at normal temperature to carry out dehydrogenation aromatization reaction, mild reaction conditions, the target compound of high conversion rate, the operation is simple, by-product little small pollution to the environment, is a completely environment-friendly preparation process. (by machine translation)