1722-14-1Relevant articles and documents
Discovery of Novel, Orally Bioavailable Pyrimidine Ether-Based Inhibitors of ELOVL1
Boyd, Michael J.,Collier, Philip N.,Clark, Michael P.,Deng, Hongbo,Kesavan, Sarathy,Ronkin, Steven M.,Waal, Nathan,Wang, Jian,Cao, Jingrong,Li, Pan,Come, Jon,Davies, Ioana,Duffy, John P.,Cochran, John E.,Court, John J.,Chandupatla, Kishan,Jackson, Katrina L.,Maltais, Francois,O’Dowd, Hardwin,Boucher, Christina,Considine, Tony,Taylor, William P.,Gao, Hong,Chakilam, Ananthisrinivas,Engtrakul, Juntyma,Crawford, Dan,Doyle, Elizabeth,Phillips, Jonathan,Kemper, Raymond,Swett, Rebecca,Empfield, James,Bunnage, Mark E.,Charifson, Paul S.,Magavi, Sanjay Shivayogi
, p. 17777 - 17794 (2021/12/17)
In our efforts to identify novel small molecule inhibitors for the treatment of adrenoleukodystrophy (ALD), we conducted a high-throughput radiometric screen for inhibitors of elongation of very long chain fatty acid 1 (ELOVL1) enzyme. We developed a seri
Selective mono-amination of dichlorodiazines
Sengmany, Stéphane,Lebre, Julie,Le Gall, Ewan,Léonel, Eric
, p. 4859 - 4867 (2015/08/03)
A mild, easy-to-perform, and versatile method for the formation of aminochlorodiazines from reaction of several types of dichlorodiazines (i.e., pyridazines, pyrimidines, and pyrazines) with primary or secondary amines in ethanol in the presence of trieth
SUBSTITUTED DIHYDROPYRAZOLONES FOR TREATING CARDIOVASCULAR AND HEMATOLOGICAL DISEASES
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Page/Page column 17, (2010/12/29)
The invention relates to dihydropyrazolon-derivatives of formula (I), to methods for their production, to their use for treating and/or for preventing diseases and their use for producing medicaments for treating and/or for preventing diseases, in particular cardiovascular and haematological diseases, kidney diseases and for promoting the healing of wounds.