17194-90-0

Basic information

• Product Name: N-[(1S)-1-phenylethyl]-benzeneacetamide
• Synonyms: N-[(1S)-1-phenylethyl]-benzeneacetamide
• CAS NO: 17194-90-0
• Molecular Weight: 239.317
• Mol File: 17194-90-0.mol
• Article Data: 29

Chemical Properties

• CAS DataBase Reference: N-[(1S)-1-phenylethyl]-benzeneacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(1S)-1-phenylethyl]-benzeneacetamide(17194-90-0)
• EPA Substance Registry System: N-[(1S)-1-phenylethyl]-benzeneacetamide(17194-90-0)

Safety Data

• Hazardous Substances Data: 17194-90-0(Hazardous Substances Data)

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 101-41-7 benzeneacetic acid methyl ester 
• 103-82-2 phenylacetic acid 
• 621-06-7 2,N-diphenylacetamide 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 103-80-0 phenylacetyl chloride 
• 100-42-5 styrene 
• 1401886-58-5 3-benzyl-1,4,2-dioxazole-5-one 
• 201230-82-2 carbon monoxide 
• 100-39-0 benzyl bromide 
• 125875-26-5 N-(2-pyridylmethylene)-(R)-1-phenylethylamine 
• 3129-98-4 (R)-benzylidene-(1-phenylethyl)amine 
• 929045-26-1 C₁₃H₁₄N₂S 
• 1158473-78-9 C₁₆H₁₄N₂S 

Downstream Products

• 103-82-2 phenylacetic acid 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 

Relevant articles and documents

Ni-Catalyzed Regiodivergent and Stereoselective Hydroalkylation of Acyclic Branched Dienes with Unstabilized C(sp3) Nucleophiles

Two complementary regiodivergent [(P,N)Ni]-catalyzed hydroalkylations of branched dienes are reported. When amides are employed as unstabilized C(sp3) nucleophiles, a highly regioselective 1,4-addition process is favored. The addition products are obtained in high yield and with excellent stereocontrol of the internal olefin. With use of a chiral ligand and imides as carbon nucleophiles, a 3,4-addition protocol was developed, enabling construction of two contiguous tertiary stereocenters in a single step with moderate to high levels of diastereocontrol and excellent enantiocontrol. Both methods operate under mild reaction conditions, display a broad scope, and show excellent functional group tolerance. The synthetic potential of the 3,4-hydroalkylation reaction was established via a series of postcatalytic modifications.

Ruthenium-Catalyzed Oxidative Amidation of Alkynes to Amides

Complex CpRuCl(PPh3)2 catalyzes reactions of terminal alkynes with 4-picoline N-oxide and primary and secondary amines to afford the corresponding amides. The reactions occur in chlorinated solvent and aqueous medium, showing applications in peptide chemistry. Stoichiometric studies reveal that the true catalysts of the processes are the vinylidene cations [CpRu(=C=CHR)(PPh3)2]+ which are oxidized to the Ru(η2-CO)-ketenes by the N-oxide. Finally, nucleophilic additions of primary and secondary amines to the free ketenes yield the corresponding amides.

CuH-Catalyzed Asymmetric Hydroamidation of Vinylarenes

A CuH-catalyzed enantioselective hydroamidation reaction of vinylarenes has been developed using readily accessible 1,4,2-dioxazol-5-ones as electrophilic amidating reagents. This method provides a straightforward and efficient approach to synthesize chiral amides in good yields with high levels of enantiopurity under mild conditions. Moreover, this transformation tolerates substrates bearing a broad range of functional groups.