17177-63-8 Usage
Description
p-Tolyl methanesulfonate, also known as methyl p-tolyl sulfonate, is a chemical compound derived from toluene, featuring a methyl group and a sulfonate group. It is recognized for its nucleophilic properties, enabling substitution reactions with various electrophiles, and is valued for its stability and reactivity in organic synthesis. Moreover, it is regarded as a relatively safe and environmentally friendly compound due to its low toxicity and minimal environmental impact.
Uses
Used in Pharmaceutical Production:
p-Tolyl methanesulfonate is utilized as an intermediate in the synthesis of various pharmaceuticals, contributing to the development of new medications and therapeutic agents.
Used in Agrochemical Production:
p-Tolyl methanesulfonate also serves as an intermediate in the production of agrochemicals, playing a role in the creation of substances that help protect and enhance crop yields.
Used in Organic Synthesis:
p-Tolyl methanesulfonate is employed as a versatile reagent in organic synthesis, facilitating a range of chemical reactions due to its ability to act as a nucleophile and engage in substitution reactions with electrophiles.
Used as a Catalyst:
In various chemical reactions, p-Tolyl methanesulfonate is used as a catalyst to increase the rate of these processes, enhancing the efficiency of chemical production and synthesis.
Used in Environmentally Friendly Applications:
Given its low toxicity and minimal environmental impact, p-Tolyl methanesulfonate is favored for applications where safety and eco-friendliness are paramount.
Check Digit Verification of cas no
The CAS Registry Mumber 17177-63-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,1,7 and 7 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 17177-63:
(7*1)+(6*7)+(5*1)+(4*7)+(3*7)+(2*6)+(1*3)=118
118 % 10 = 8
So 17177-63-8 is a valid CAS Registry Number.
17177-63-8Relevant articles and documents
Electrochemical cross-coupling reactions of sodium arenesulfinates with thiophenols and phenols
Ma, Jinfeng,Xu, Pan,Zhong, Zijian,Zhou, Aihua
supporting information, (2021/10/26)
A green electrochemical oxidative cross-coupling protocol for the generation of thiosulfonates and sulfonate esters using sodium arenesulfinates and thiophenols/phenols is disclosed. The protocol involves using inorganic and non-toxic NaI as both redox catalyst and supporting electrolyte at room temperature without oxidant and base. The reactions provide good yields of products and tolerate broad substrate scope. The mechanistic studies revealed that the reactions proceed via a radical pathway for the formation of SO2–S and SO2–O bonds.
Chromatography-Free and Eco-Friendly Synthesis of Aryl Tosylates and Mesylates
Lei, Xiangyang,Jalla, Anusha,Abou Shama, Mhd A.,Stafford, Jamie M.,Cao, Billy
supporting information, p. 2578 - 2585 (2015/09/01)
Two chromatography-free and eco-friendly protocols have been developed to synthesize aryl tosylates and mesylates by the tosylation and mesylation of the corresponding hydroxyarenes, respectively. These protocols are superior to other known ones regarding
Palladium-catalyzed intra-and intermolecular C-H arylation using mesylates: Synthetic scope and mechanistic studies
Ferguson, Devin M.,Rudolph, Stacey R.,Kalyani, Dipannita
, p. 2395 - 2401 (2014/07/21)
This paper describes the development of Pd-catalyzed inter-and intramolecular direct arylation using mesylates. Furthermore, a sequential mesylation/arylation protocol using phenols as substrates is described. These transformations are general with respect to the electronics of the C-H substrates and allow for the synthesis of diverse heterocyclic motifs in good yields. Both arenes and heteroarenes efficiently participate in these reactions. Preliminary mechanistic studies are presented for both inter-and intramolecular arylations.
