171011-37-3

Basic information

• Product Name: (4-bromo-1,2-phenylene)dimethanol
• Synonyms: (4-bromo-1,2-phenylene)dimethanol;[4-bromo-2-(hydroxymethyl)phenyl]methanol;1,2-Benzenedimethanol, 4-bromo-;(4-Bromo-1,2-phenylene)
• CAS NO: 171011-37-3
• Molecular Formula: C₈H₉BrO₂
• Molecular Weight: 217.05986
• Mol File: 171011-37-3.mol
• Article Data: 26

Chemical Properties

• Melting Point: 84 °C
• Boiling Point: 361.8±32.0 °C(Predicted)
• Appearance: /
• Density: 1.628±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.06±0.10(Predicted)
• CAS DataBase Reference: (4-bromo-1,2-phenylene)dimethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (4-bromo-1,2-phenylene)dimethanol(171011-37-3)
• EPA Substance Registry System: (4-bromo-1,2-phenylene)dimethanol(171011-37-3)

Safety Data

• Hazardous Substances Data: 171011-37-3(Hazardous Substances Data)

Usage

Description

(4-bromo-1,2-phenylene)dimethanol is a brominated diol chemical compound with the formula C8H10Br2O2. It features two hydroxyl (OH) functional groups and a bromine atom attached to a phenylene (benzene) ring.

Uses

Used in Pharmaceutical Industry:
(4-bromo-1,2-phenylene)dimethanol is used as a building block for the synthesis of various pharmaceuticals due to its unique structure and functional groups.
Used in Agrochemical Industry:
(4-bromo-1,2-phenylene)dimethanol is used as a building block for the synthesis of agrochemicals, contributing to the development of effective and targeted products for agricultural applications.
Used in Materials Science:
(4-bromo-1,2-phenylene)dimethanol is used as a building block in the synthesis of various materials, including polymers and resins, due to its ability to act as a crosslinking agent.
Used as a Crosslinking Agent in Polymer and Resin Production:
(4-bromo-1,2-phenylene)dimethanol is used as a crosslinking agent in the production of polymers and resins, enhancing their properties and performance.
Note: The handling of (4-bromo-1,2-phenylene)dimethanol should be done with caution, as brominated chemicals can pose hazards to human health and the environment if not properly managed.

Upstream product

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Downstream Products

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• 660830-62-6 ethyl 7-bromoisoquinoline-3-carboxylate 
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• 220513-49-5 5-bromo-1,3-dihydroisobenzofuran 
• 268232-33-3 1,2-bis(tert-butyldimethylsilanyloxymethyl)-4-iodobenzene 
• 1609574-36-8 3-[3,4-bis(tert-butoxycarboinylaminoethyl)phenyl]propan-1-ol 
• 1609574-33-5 methyl 3-[3,4-bis(tert-butoxycarboinylaminoethyl)phenyl]propanoate 
• 1609574-30-2 (E)-methyl 3-[3,4-bis(tert-butoxycarbonylaminoethyl)phenyl]acrylate 
• 1609573-80-9 4-bromo-1,2-bis(tert-butoxycarbonylaminoethyl)benzene 

Relevant articles and documents

Live-Cell Localization Microscopy with a Fluorogenic and Self-Blinking Tetrazine Probe

Recent developments in fluorescence microscopy call for novel small-molecule-based labels with multiple functionalities to satisfy different experimental requirements. A current limitation in the advancement of live-cell single-molecule localization micro

Structure-Activity Studies with Bis-Amidines That Potentiate Gram-Positive Specific Antibiotics against Gram-Negative Pathogens

Pentamidine, an FDA-approved antiparasitic drug, was recently identified as an outer membrane disrupting synergist that potentiates erythromycin, rifampicin, and novobiocin against Gram-negative bacteria. The same study also described a preliminary structure-activity relationship using commercially available pentamidine analogues. We here report the design, synthesis, and evaluation of a broader panel of bis-amidines inspired by pentamidine. The present study both validates the previously observed synergistic activity reported for pentamidine, while further assessing the capacity for structurally similar bis-amidines to also potentiate Gram-positive specific antibiotics against Gram-negative pathogens. Among the bis-amidines prepared, a number of them were found to exhibit synergistic activity greater than pentamidine. These synergists were shown to effectively potentiate the activity of Gram-positive specific antibiotics against multiple Gram-negative pathogens such as Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli, including polymyxin- and carbapenem-resistant strains.

Optimization of Orally Bioavailable PI3KδInhibitors and Identification of Vps34 as a Key Selectivity Target

Optimization of a lead series of PI3Kδinhibitors based on a dihydroisobenzofuran core led to the identification of potent, orally bioavailable compound 19. Selectivity profiling of compound 19 showed similar potency for class III PI3K, Vps34, and PI3Kδ, and compound 19 was not well-tolerated in a 7-day rat toxicity study. Structure-based design led to an improvement in selectivity for PI3Kδover Vps34 and, a focus on oral phramacokinetics properties resulted in the discovery of compound 41, which showed improved toxicological outcomes at similar exposure levels to compound 19.