16793-89-8

Basic information

• Product Name: 1-(2-BROMOETHYL)-2-NITROBENZENE
• Synonyms: 2-Nitrophenethyl broMide 97%;1-(2-BROMOETHYL)-2-NITROBENZENE;2-Nitrophenethyl bromide;2-(2-Bromoethyl)nitrobenzene;2-(o-Nitrophenyl)ethyl bromide;o-Nitrophenethyl bromide
• CAS NO: 16793-89-8
• Molecular Formula: C₈H₈BrNO₂
• Molecular Weight: 230.06
• Product Categories: Building Blocks;Chemical Synthesis;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks
• Mol File: 16793-89-8.mol
• Article Data: 13

Chemical Properties

• Melting Point: 34-38 °C
• Boiling Point: 127-130 °C/1 mmHg
• Flash Point: 125.3°C
• Appearance: /
• Density: 1.562g/cm³
• Vapor Pressure: 0.00538mmHg at 25°C
• Refractive Index: 1.595
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(2-BROMOETHYL)-2-NITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-BROMOETHYL)-2-NITROBENZENE(16793-89-8)
• EPA Substance Registry System: 1-(2-BROMOETHYL)-2-NITROBENZENE(16793-89-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 16793-89-8(Hazardous Substances Data)

Usage

Description

1-(2-BROMOETHYL)-2-NITROBENZENE is an organic compound that features a bromoethyl group attached to a nitrobenzene ring. This chemical structure endows it with unique properties that make it suitable for various applications in different industries.

Uses

Used in Pharmaceutical Industry:
1-(2-BROMOETHYL)-2-NITROBENZENE is used as a reactant for the synthesis of N-(ureidoalkyl)benzylpiperidines, which are known as CCR3 receptors antagonists. These antagonists play a crucial role in the development of drugs targeting inflammatory and allergic diseases by modulating the immune response.
Used in Electrochemistry:
In the field of electrochemistry, 1-(2-BROMOETHYL)-2-NITROBENZENE serves as a reactant for reduction at carbon cathodes. This process is essential for studying the electrochemical properties of the compound and exploring its potential applications in energy storage and conversion systems, such as batteries and fuel cells.
Overall, 1-(2-BROMOETHYL)-2-NITROBENZENE is a versatile organic compound with applications in the pharmaceutical and electrochemistry industries, making it a valuable asset for researchers and scientists working in these fields.

InChI:InChI=1/C8H8BrNO2/c9-6-5-7-3-1-2-4-8(7)10(11)12/h1-4H,5-6H2

Upstream product

• 579-71-5 2-nitrostyrene 
• 552-89-6 2-nitro-benzaldehyde 
• 69628-96-2 p-toluenesulfonic acid o-nitrophenethyl ester 
• 15121-84-3 2-nitro-benzeneethanol 
• 31912-02-4 ethyl 2-nitrophenylacetate 
• 103-63-9 1-phenyl-2-bromoethane 

Downstream Products

• 33100-15-1 2-(2-aminoethyl)nitrobenzene 
• 455260-02-3 4-benzyl-1-[2-(2-nitro-phenyl)ethyl]piperidine 
• 120-72-9 indole 
• 479500-92-0 1,1'-biindolyl 
• 579-71-5 2-nitrostyrene 
• 5339-23-1 1-(2-nitrophenethyl)piperidine 
• 455260-08-9 2-{2-[4-(4-fluoro-benzyl)piperidin-1-yl]ethyl}phenylamine 
• 455259-97-9 2-[2-(4-benzyl-piperidin-1-yl)ethyl]phenylamine 
• 874570-85-1 (1-benzyl-piperidin-4-yl)-[2-(2-nitrophenyl)-ethyl]-amine 
• 86499-31-2 ethyl 2-(acetylamino)-2-(ethoxycarbonyl)-4-(2-nitrophenyl)butanoate 
• 48148-55-6 N-(o-Nitrophenaethyl)-aethylendiamin 
• 3478-91-9 dimethyl-(2-nitro-phenethyl)-amine 
• 496-15-1 1-indoline 
• 2001-32-3 3-(2-nitrophenyl)propionic acid 

Relevant articles and documents

Direct Arylation of Distal and Proximal C(sp3)-H Bonds of t-Amines with Aryl Diazonium Tetrafluoroborates via Photoredox Catalysis

A visible light-mediated arylation protocol for t-amines has been reported through the coupling of γ- and α-amino alkyl radicals with different aryl diazonium salts using Ru(bpy)3Cl2·6H2O as a photocatalyst. Structurally different 9-aryl-9,10-dihydroacridine, 1-aryl tetrahydroisoquinoline, hexahydropyrrolo[2,1-a]isoquinoline, and hexahydro-2H-pyrido[2,1-a]isoquinoline frameworks with different substitution patterns have been synthesized in good yield using this methodology.

Reduction of 1-(2-Chloroethyl)-2-nitrobenzene and 1-(2-Bromoethyl)-2- nitrobenzene at carbon cathodes: Electrosynthetic routes to 1-nitro-2- vinylbenzene and 1H -indole

Studies of the electrochemical reductions of 1-(2-chloroethyl)-2- nitrobenzene (1) and 1-(2-bromoethyl)-2-nitrobenzene (2) at carbon cathodes in dimethylformamide (DMF) containing tetramethylammonium tetrafluoroborate (TMABF4) have been undertaken. Cyclic voltammograms for 1 and 2 exhibit three irreversible cathodic peaks, the first of which is attributed to one-electron reduction of the nitro group, and the resulting nitro radical-anion immediately reacts as a base with the adjacent alkyl halide moiety via an E2 elimination to produce 1-nitro-2-vinylbenzene. At a potential corresponding to the first cathodic peak, bulk electrolyses of 1 or 2 in the absence of a proton donor afford 1-nitro-2-vinylbenzene as principal product, along with 1H -indole and a dimeric species. However, when 1 or 2 is electrolyzed in the presence of either phenol or 2,4-pentanedione as a proton source, the only significant product is 1H -indole. A mechanistic picture for the reductions of 1 and 2 is proposed, and a separate examination of the electrochemical behavior of 1-nitro-2-vinylbenzene has been included as part of this work.

CGRP receptor antagonists

The present invention relates to CGRP receptor antagonists, pharmaceutical compositions thereof, and methods therewith for treating CGRP receptor-mediated diseases and conditions.