16576-23-1

Basic information

• Product Name: 1-ISOQUINOLINYL PHENYL KETONE
• Synonyms: AKOS BBS-00001134;1-BENZOYLISOQUINOLINE;1-ISOQUINOLINYL PHENYL KETONE;ISOQUINOLIN-1-YL(PHENYL)METHANONE;1-BENZOYLISOQUINOLINE 98%
• CAS NO: 16576-23-1
• Molecular Formula: C₁₆H₁₁NO
• Molecular Weight: 233.26
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Isoquinolines
• Mol File: 16576-23-1.mol
• Article Data: 42

Chemical Properties

• Melting Point: 76-79 °C(lit.)
• Boiling Point: 418.5 °C at 760 mmHg
• Flash Point: 212.9 °C
• Appearance: /
• Density: 1.196 g/cm³
• Vapor Pressure: 3.26E-07mmHg at 25°C
• Refractive Index: 1.66
• CAS DataBase Reference: 1-ISOQUINOLINYL PHENYL KETONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ISOQUINOLINYL PHENYL KETONE(16576-23-1)
• EPA Substance Registry System: 1-ISOQUINOLINYL PHENYL KETONE(16576-23-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 16576-23-1(Hazardous Substances Data)

Usage

Description

1-Isoquinolinyl phenyl ketone (Iquinpk) is an organic compound that is known for its reactivity with various metal complexes. It possesses unique chemical properties that allow it to form novel complexes with different metal ions, making it a versatile compound in the field of chemical synthesis and coordination chemistry.

Uses

Used in Chemical Synthesis:
1-Isoquinolinyl phenyl ketone is used as a reagent for the formation of novel metal complexes. It reacts with metal complexes such as ReCl3(MeCN)(PPh3)] to give [ReCl3(N-O)(PPh3)], and with the [ReOBr3(PPh3)2] complex in acetone to yield a new complex, [ReOBr2(iquinpk-OH)(PPh3)]. These reactions highlight the potential of Iquinpk in the synthesis of new coordination compounds with potential applications in various fields, including catalysis, pharmaceuticals, and materials science.
Used in Coordination Chemistry:
In the field of coordination chemistry, 1-Isoquinolinyl phenyl ketone is used as a ligand to form complexes with metal ions. Its ability to coordinate with metal ions and influence their reactivity makes it a valuable tool for studying the properties and applications of metal complexes. This can lead to the development of new catalysts, sensors, and other functional materials.
Used in Pharmaceutical Research:
The unique reactivity and coordination properties of 1-Isoquinolinyl phenyl ketone make it a promising candidate for the development of new pharmaceutical compounds. By forming complexes with metal ions, Iquinpk can potentially be used to design novel drugs with improved efficacy and selectivity. Further research in this area could lead to the discovery of new therapeutic agents for various diseases and medical conditions.
Used in Materials Science:
The formation of metal complexes with 1-Isoquinolinyl phenyl ketone can also be applied in the field of materials science. These complexes may exhibit unique optical, electronic, or magnetic properties that can be harnessed for the development of advanced materials with potential applications in electronics, sensors, and other high-tech industries.

InChI:InChI=1/C16H11NO/c18-16(13-7-2-1-3-8-13)15-14-9-5-4-6-12(14)10-11-17-15/h1-11H

Upstream product

• 27302-13-2 α-phenyl-1-isoquinolineacetonitrile 
• 486-73-7 1-isoquinolinecarboxylic acid 
• 98-88-4 benzoyl chloride 
• 1532-72-5 isoquinoline N-oxide 
• 102-96-5 (2-nitroethenyl)benzene 
• 705-60-2 (2-nitroprop-1-enyl)benzene 
• 15341-31-8 ((Z)-(1-nitroethene-1,2-diyl)dibenzene) 
• 119-65-3 isoquinoline 
• 100-46-9 benzylamine 
• 24853-83-6 1-benzyl-3,4-dihydro-isoquinoline 
• 1074-12-0 phenylglyoxal hydrate 
• 613-94-5 benzoic acid hydrazide 
• 98-86-2 acetophenone 
• 103-82-2 phenylacetic acid 

Downstream Products

• 10175-00-5 1-(α-Hydroxybenzyl)isoquinoline 
• 124104-88-7 15-phenyl-benz[h]isoquino[2,1-b]isoquinolinylium; bromide 
• 1567388-98-0 2-aza-14-oxo-12-phenyltetracyclo[11.4.0.02,11,05,10]heptdeca-1⁽¹³⁾,3,5⁽¹⁰⁾,6,8,11-hexaene 
• 1567388-96-8 12-acetyl-1-aza-11-phenyltricyclo[8.3.0.04,9]trideca-2,4⁽⁹⁾,5,7,10,12-hexaene 
• 1222807-61-5 1-benzoylisoquinoline thiosemicarbazone 
• 105702-31-6 α-(methylsulfonylmethyl)-α-phenyl-1-isoquinolinemethanol 
• 10349-56-1 α-(methylsulfinylmethyl)-α-phenyl-1-isoquinolinemethanol 

Relevant articles and documents

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Metal-Free Photoinduced Deformylative Minisci-Type Reaction

A metal-free deformylative Minisci-type reaction is disclosed by using aliphatic aldehydes as alkyl radical precursors. The reaction proceeds via a sequence of hydrogen atom abstraction (HAA) from aldehyde and decarbonylation under mild photochemical conditions. The transformation offers many advantages including good regioselectivity, broad substrate scope, and easy operation. The reaction is also amenable to late-stage functionalization of complex heteroarenes, and can be readily performed on gram scale. (Figure presented.).

K2S2O8activation by glucose at room temperature for the synthesis and functionalization of heterocycles in water

While persulfate activation at room temperature using glucose has primarily been focused on kinetic studies of the sulfate radical anion, the utilization of this protocol in organic synthesis is rarely demonstrated. We reinvestigated selected K2S2O8-mediated known organic reactions that invariably require higher temperatures and an organic solvent. A diverse, mild functionalization and synthesis of heterocycles using the inexpensive oxidant K2S2O8 in water at room temperature is reported, demonstrating the sustainability and broad scope of the method. Unlike traditional methods used for persulfate activation, the current method uses naturally abundant glucose as a K2S2O8 activator, avoiding the use of higher temperature, UV light, transition metals or bases.

Highly chemoselective deoxygenation of N-heterocyclic: N -oxides under transition metal-free conditions

Because their site-selective C-H functionalizations are now considered one of the most useful tools for synthesizing various N-heterocyclic compounds, the highly chemoselective deoxygenation of densely functionalized N-heterocyclic N-oxides has received much attention from the synthetic chemistry community. Here, we provide a protocol for the highly chemoselective deoxygenation of various functionalized N-oxides under visible light-mediated photoredox conditions with Na2-eosin Y as an organophotocatalyst. Mechanistic studies imply that the excited state of the organophotocatalyst is reductively quenched by Hantzsch esters. This operationally simple technique tolerates a wide range of functional groups and allows high-yield, multigram-scale deoxygenation. This journal is