16564-43-5 Usage
Description
GLYCOCHENODEOXYCHOLIC ACID SODIUM SALT is a bile acid salt that is the sodium salt of glycochenodeoxycholic acid. It is a white to off-white powder formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.
Uses
Used in Pharmaceutical Industry:
GLYCOCHENODEOXYCHOLIC ACID SODIUM SALT is used as a pharmaceutical agent for its cholagogue and choleretic properties, aiding in the treatment of various liver and gallbladder disorders.
Used in Research Applications:
GLYCOCHENODEOXYCHOLIC ACID SODIUM SALT is used as a research tool to assess the repair of DNA damage induced by bile salts, providing valuable insights into the mechanisms of cellular response to bile acid-induced stress.
Used in Microbiology Research:
In microbiology, GLYCOCHENODEOXYCHOLIC ACID SODIUM SALT is used to investigate enterotoxin production by Clostridium perfringens type A in the presence of human bile salts, contributing to the understanding of the role of bile salts in bacterial pathogenesis.
Purification Methods
Dissolve it in EtOH, filter it and concentrate it to crystallisation, and recrystallise from a little EtOH. It also recrystallises from EtOH/Et2O. [Beilstein 10 IV 1611.]
Check Digit Verification of cas no
The CAS Registry Mumber 16564-43-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,5,6 and 4 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 16564-43:
(7*1)+(6*6)+(5*5)+(4*6)+(3*4)+(2*4)+(1*3)=115
115 % 10 = 5
So 16564-43-5 is a valid CAS Registry Number.
InChI:InChI=1/C26H43NO5.Na/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29;/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-;/m1./s1
16564-43-5Relevant articles and documents
Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts
Venturoni, Francesco,Gioiello, Antimo,Sardella, Roccaldo,Natalini, Benedetto,Pellicciari, Roberto
experimental part, p. 4109 - 4115 (2012/06/15)
A multi-gram scale protocol for the N-acyl amidation of bile acids with glycine and taurine has been successfully developed under continuous flow processing conditions. Selecting ursodeoxycholic acid (UDCA) as the model compound and N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) as the condensing agent, a modular mesoreactor assisted flow set-up was employed to significantly speed up the optimization of the reaction conditions and the flow scale-up synthesis. The results in terms of yield, in line purification, analysis, and implemented flow set-up for the reaction optimization and large scale production are reported and discussed.
