16560-26-2

Basic information

• Product Name: 2-oxo-4-phenyl-2H-chromene-3-carbonitrile
• Synonyms: 2-oxo-4-phenyl-2H-chromene-3-carbonitrile
• CAS NO: 16560-26-2
• Molecular Weight: 247.253
• Mol File: 16560-26-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-oxo-4-phenyl-2H-chromene-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-oxo-4-phenyl-2H-chromene-3-carbonitrile(16560-26-2)
• EPA Substance Registry System: 2-oxo-4-phenyl-2H-chromene-3-carbonitrile(16560-26-2)

Safety Data

• Hazardous Substances Data: 16560-26-2(Hazardous Substances Data)

Upstream product

• 5232-99-5 etocrylene 
• 10380-41-3 2-cyano-3,3-diphenylacrylic acid 
• 119-61-9 benzophenone 
• 54758-71-3 2-(imino(phenyl)methyl)phenol 
• 105-56-6 ethyl 2-cyanoacetate 
• 475576-71-7 3-cyano-2-imino-4-phenyl-2H-chromene 

Relevant articles and documents

Synthesis of coumarins via PIDA/I2-mediated oxidative cyclization of substituted phenylacrylic acids

A variety of functionalized coumarins were synthesized from substituted phenylacrylic acids via PIDA/I2-mediated and irradiation-promoted oxidative carbon-oxygen bond formation. Our studies show that the oxygen in the pendant carboxylic acid group cyclizes favorably to the aryl ring that is cis to it. The main advantages of this method include good functional group tolerance and the transition-metal-free characteristic. The Royal Society of Chemistry 2013.

Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof

The present invention is directed to substituted coumarins and quinolines and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.