164162-36-1 Usage
Description
2-(tert-butyldiMethylsilyl)oxyl alcohol trifluorin methanesulfonate is a chemical compound that serves as an organic synthesis intermediate and pharmaceutical intermediate. It is primarily utilized in laboratory research and development processes, as well as in chemical production processes.
Uses
Used in Organic Synthesis:
2-(tert-butyldiMethylsilyl)oxyl alcohol trifluorin methanesulfonate is used as an organic synthesis intermediate for facilitating various chemical reactions and the formation of new compounds. Its unique structure allows it to act as a versatile building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(tert-butyldiMethylsilyl)oxyl alcohol trifluorin methanesulfonate is used as a pharmaceutical intermediate. It plays a crucial role in the development of new drugs and the improvement of existing ones, contributing to the advancement of medicine and healthcare.
Used in Laboratory Research and Development:
2-(tert-butyldiMethylsilyl)oxyl alcohol trifluorin methanesulfonate is employed in laboratory research and development processes to explore its potential applications and properties. This helps scientists and researchers to better understand its behavior and reactivity, leading to the discovery of new uses and applications.
Used in Chemical Production Process:
In the chemical production process, 2-(tert-butyldiMethylsilyl)oxyl alcohol trifluorin methanesulfonate is utilized to manufacture various chemical products. Its presence in the production process ensures the synthesis of high-quality products with desired properties, contributing to the efficiency and effectiveness of the overall process.
Synthesis
The reaction was carried out under a nitrogen atmosphere. TBS- ethylene glycol prepared as per step 1 (85.10g, 0.48 mol) and 2, 6-Lutidine (84.28ml, 0.72 mol) were stirred in n-heptane (425ml) to give a clear solution which was then cooled to -15 to - 25°C. Trifluoromethanesulfonic anhydride (Tf2O) (99.74 ml, 0.590 mol) was added drop-wise over a period of 45 minutes to the n-heptane solution (white precipitate starts to form immediately) while maintaining the reaction at -15 to -25°C. The reaction mixture was kept at temperature between -15 to -25°C for 2 hours. The precipitate generated was filtered off. The filtrate was then evaporated up to ~2 volumes with respect to TBS-ethyiene glycol (~200 ml).
Check Digit Verification of cas no
The CAS Registry Mumber 164162-36-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,4,1,6 and 2 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 164162-36:
(8*1)+(7*6)+(6*4)+(5*1)+(4*6)+(3*2)+(2*3)+(1*6)=121
121 % 10 = 1
So 164162-36-1 is a valid CAS Registry Number.
164162-36-1Relevant articles and documents
RAPAMYCIN ANALOGS AND USES THEREOF
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Paragraph 0349-00350, (2020/01/08)
The present invention provides compounds, compositions thereof, and methods of using the same.
Preparation method of everolimus intermediate
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, (2017/12/30)
The invention discloses a preparation method of an everolimus intermediate. The preparation method comprises the following steps: reacting ethylene glycol and tert-butyldimethylsilyl chloride in inert solvents such as dichloromethane at the temperature of 35 DEG C below zero to 25 DEG C below zero in the presence of organic base to obtain 2-(tert-dimethylsiloxy)ethyl alcohol; reacting the 2-(tert-dimethylsiloxy)ethyl alcohol and trifluoromethanesulfonic anhydride in the presence of the organic base to obtain trifluoromethanesulfonic acid 2-(tert-dimethylsiloxy)ethyl ester. According to the method disclosed by the invention, the generation of a disubstituted by-product can be greatly reduced, and further a monosubstituted product 2-(tert-dimethylsiloxy) ethyl alcohol with relatively-high purity and yield is obtained.
PYRIDINE DERIVATIVES AS DGAT-1 INHIBITORS
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Page/Page column 20; 37-38, (2014/09/29)
Described herein are compounds of formula (I): The compounds of formula (I) act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.
