1636-25-5

Basic information

• Product Name: ethylphenylmalonic acid
• Synonyms: ethylphenylmalonic acid;Ethyl(phenyl)propanedioic acid
• CAS NO: 1636-25-5
• Molecular Formula: C₁₁H₁₂O₄
• Molecular Weight: 208.21058
• EINECS: 216-663-6
• Mol File: 1636-25-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 377°Cat760mmHg
• Flash Point: 196°C
• Appearance: /
• Density: 1.286g/cm³
• Vapor Pressure: 2.36E-06mmHg at 25°C
• Refractive Index: 1.56
• CAS DataBase Reference: ethylphenylmalonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: ethylphenylmalonic acid(1636-25-5)
• EPA Substance Registry System: ethylphenylmalonic acid(1636-25-5)

Safety Data

• Hazardous Substances Data: 1636-25-5(Hazardous Substances Data)

Usage

General Description

Ethylphenylmalonic acid is a chemical compound with the molecular formula C12H14O4. It is an organic compound that is commonly used in the synthesis of pharmaceuticals and other organic compounds. Ethylphenylmalonic acid is a white crystalline solid at room temperature and is soluble in water and alcohol. It is primarily used as a building block in the creation of various organic compounds, and its carboxylic acid functional group makes it a versatile intermediate in organic synthesis. Overall, ethylphenylmalonic acid plays a crucial role in the production of a wide range of pharmaceuticals and organic compounds due to its chemical reactivity and stability.

InChI:InChI=1/C11H12O4/c1-2-11(9(12)13,10(14)15)8-6-4-3-5-7-8/h3-7H,2H2,1H3,(H,12,13)(H,14,15)

Upstream product

• 50-06-6 phenobarbital 
• 76-67-5 diethyl ethyl(phenyl)malonate 
• 30006-28-1 2,4-dithiophenobarbital 
• 75-03-6 ethyl iodide 
• 2613-89-0 phenylmalonic acid 
• 115-38-8 mephobarbital 

Downstream Products

• 54095-15-7 2-ethyl-2-phenylmalonyldichloride 
• 108953-96-4 5-ethyl-2,2-dimethyl-5-phenyl-1,3-dioxane-4,6-dione 
• 80278-08-6 5-ethyl-2-methoxy-5-phenyl-dihydro-pyrimidine-4,6-dione 
• 50-06-6 phenobarbital 
• 52699-46-4 1-(2-phenyl-butyryl)-1H-imidazole 
• 93406-17-8 N-benzyl-2-phenylbutanamide 
• 149636-79-3 racem.-2-Ethyl-4-phenyl-hexadien-(2,3)-carbonsaeure 
• 38701-10-9 2,4-Diaethyl-4-phenylbutadien-(2,3)-carbonsaeure-aethylester 
• 38701-07-4 2-Methyl-4-aethyl-4-phenyl-butadien-(2,3)-carbonsaeureaethylester 
• 57585-23-6 racem.-2-Methyl-4-phenyl-hexadien-(2,3)-carbonsaeure 
• 101730-03-4 2-ethyl-2,N-diphenyl-malonamic acid methyl ester 
• 132494-17-8 ethyl-phenyl-malonic acid monoisopropyl ester 
• 108516-37-6 monomethyl ethylphenylmalonate 
• 857411-80-4 5-ethyl-2-methoxy-5-phenyl-1H-pyrimidine-4,6-dione 

Relevant articles and documents

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Hydrolysis of 2,4-dithiophenobarbital

Hydrolysis of 2,4-dithiophenobarbital in aqueous solutions of pH 2 - 12 was investigated at 40 and 60°C using UV spectrophotometry. The values of reaction order, rate constants, pKal and pKa2 and activation energy were determined. The preliminary estimation of degradation products was accomplished using thin layer chromatography. The major products were isolated by circular chromatography and identified by spectroscopic and classical methods.

N-Alkyl barbiturates. A series of compounds for the study of metabolic structure-activity relationships

Many therapeutic agents are metabolised along multiple pathways, but up to now there have been few investigations addressing the question of which chemical features of drugs govern the participation in, and quantitative significance of, different biotransformation pathways. To assess the influence of variations of the chemical structure upon metabolim, a series of novel barbiturate analogues has been synthesized. The N1-monoalkylated and N1,N2-dialkylated phenobarbitones and 2-desoxyphenobarbitones have been synthesized via condensation of ethylphenylmalonic acid derivatives with different N-alkylated ureas or thioureas, and/or by base-catalyzed N-alkylation of different barbituric acids.