16347-60-7Relevant articles and documents
Aluminium nitrate-catalyzed one-pot synthesis of 4(3h)-quinazolinones by a three-component coupling of anthranilic acid, amines, and ortho esters
Wang, Min,Song, Zhiguo,Zhang, Tingting
, p. 385 - 391 (2011)
The one-pot synthesis of quinazolinone derivatives from the reaction of anthranilic acid, amines, and ortho esters in the presence of aluminium nitrate has been carried out. The reaction occurred in a few minutes at room temperature under solvent-free con
Zirconyl(IV) chloride catalyzed three component one-pot synthesis of quinazolin-4(3H)-ones
Sangshetti, Jaiprakash N.,Kokare, Nagnnath D.,Shinde, Devanand B.
, p. 1289 - 1291 (2007)
An efficient one-pot method for synthesis of an array of quinazolin-4(3H)-ones from anthranilic acid, triethyl orthoformate, and amines using ZrOCl2 is described. This method offers improvements for the synthesis of quinazolin-4(3H)-ones with r
Dimerization of substituted 2-aminobenzoic acids under Vilsmeier conditions: A novel route to the synthesis of 4-(3H)-quinazolinones
Majo, Vattoly J.,Perumal, Paramasivan T.
, p. 5015 - 5018 (1996)
Various substituted 2-aminobenzoic acids on treatment with Vilsmeier reagent (DMF/POCl3) at 80-90°C undergo a novel dimerization reaction to yield 2-[3,4-dihydro-4-oxo-3-quinazolinoyl]-N,N-dimethyl benzamides. The interruption of dimerization a
Synthesis of 3-Aryl-4(3H)-quinazolinones from anthranilic acid, ortho esters, and anilines using Ce(CH3SO3)3· 2H2O as catalyst
Wang, Min,Song, Zhi-Guo,Zhang, Ting-Ting
, p. 993 - 996 (2010)
3-Aryl-4(3H)-quinazolinones were synthesized efficiently by the three component one-pot cyclocondensation of anthranilic acid, ortho esters, and anilines in the presence of Ce(CH3SO3)3·2H 2O at room temperature under solve
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Wagner
, p. 133,137 (1940)
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A convenient synthesis of substituted quinazolin-4(3H)-ones under microwave and solvent-free conditions
Montazeri, Nasser,Rad-Moghadam, Kurosh
, p. 2533 - 2536 (2004)
A clean and facile synthesis of the title compounds is achieved from cyclocondensation of 2-aminobenzamides with orthoesters catalyzed by SiO 2/H2SO4 in dry and microwave conditions.
Synthesis method of 4-3(H)quinazolinone and its derivatives
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Paragraph 0061-0064; 0067-0068; 0072, (2022/03/31)
The present invention provides a method for synthesizing 4- (3H) quinazolinone and derivatives thereof (formula III), the method takes imidazole hydrochloride as the catalyst, in the absence of other catalysts or additives, by the one-pot method of synthesis of 2,3-di substituted quinazolinone and its derivatives by a pot method of 2,3-di substituted quinazolinone and its derivatives. The synthesis method of the present invention has good functional group tolerance, capable of synthesizing 4-(3H) quinazolinone and its derivatives for research in drugs or other fields. The synthesis method of the present invention does not use dichloromethane, nor does it use a corrosive concentrated hydrochloric acid and metal catalyst, while not requiring harsh reaction conditions, no gas protection, no autoclave, the reaction time is short, has a certain value in industrial production.
N,N-Dimethylformamide as Carbon Synthons for the Synthesis ofN-Heterocycles: Pyrrolo/Indolo[1,2-a]quinoxalines and Quinazolin-4-ones
Ding, Chengcheng,Li, Shichen,Ma, Chen,Ren, Jianing,Wang, Yishou
, p. 16848 - 16857 (2021/12/06)
N,N-dimethylformamide (DMF) as synthetic precursors contributing especially the methyl, acyl, and amino groups has played a significant role in heterocycle syntheses and functionalization. In this protocol, a wide range of pyrrolo/indolo[1,2-a]quinoxalines and quinazolin-4-ones were obtained in moderate to good yields by using elemental iodine without any metal or peroxides. We considered thatN-methyl andN-acyl of DMF participate and complete the reaction separately through different mechanisms, which displayed potential still to be explored of DMF.
Metal-free C-H methylation and acetylation of heteroarenes with PEG-400
Kudale, Vishal Suresh,Wang, Jeh-Jeng
supporting information, p. 3506 - 3511 (2020/06/25)
The generation of a methyl carbon source from renewable and cheap sources is challenging. Herein, we describe a novel and an efficient route for methylation and acetylation of aza-heteroarenes using PEG-400 under O2and TsOH·H2O for the first time by tuning the reaction conditions using a different set of starting materials. The key features of the current protocol are oxidative C-O and C-C bond scission under metal-free conditions with good functional group tolerance, and a broad substrate scope. The potential applicability of the designed methodology was demonstrated for the synthesis of central nervous system (CNS) depressant and anticonvulsant drug molecules by a one-pot strategy.