162377-69-7

Basic information

• Product Name: N-benzoyl-L-tert-leucine butyl ester
• Synonyms: N-benzoyl-L-tert-leucine butyl ester
• CAS NO: 162377-69-7
• Molecular Weight: 291.39
• Mol File: 162377-69-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-benzoyl-L-tert-leucine butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzoyl-L-tert-leucine butyl ester(162377-69-7)
• EPA Substance Registry System: N-benzoyl-L-tert-leucine butyl ester(162377-69-7)

Safety Data

• Hazardous Substances Data: 162377-69-7(Hazardous Substances Data)

Upstream product

• 71953-55-4 2-phenyl-4-tert-butyloxazolin-5(4H)-one 
• 71-36-3 butan-1-ol 

Downstream Products

• 20859-02-3 L-tert-Leucine 
• 162377-68-6 (S)-2-benzoylamino-3,3-dimethylbutyric acid 

Relevant articles and documents

Synthesis of homochiralL-(S)-tert-leucine via a lipase catalysed dynamic resolution process

Treatment of (±)-2-phenyl-4-tert-butyloxazolin-5(4H)-one 8 with Lipozyme (Mucor miehei) in toluene containing n-butanol and a catalytic amount of triethylamine resulted in a 94% yield of (S)-N-benzoyltert-leucine butyl ester 9 (99.5% e.e.). Subsequent two step hydrolysis (Alcalase followed by 6N HCl, reflux) yielded homochiral L-(S)-tert-leucine 1.