161957-57-9 Usage
Description
1-(2-Chloro-3-fluorophenyl)ethanone is an organic compound with the molecular formula C8H6ClFOK. It is a derivative of acetophenone, featuring a chlorine atom at the 2nd position and a fluorine atom at the 3rd position on the phenyl ring. 1-(2-Chloro-3-fluorophenyl)ethanone is known for its potential applications in the pharmaceutical and chemical industries due to its unique structural properties.
Uses
1. Used in Pharmaceutical Industry:
1-(2-Chloro-3-fluorophenyl)ethanone is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structural features make it a valuable building block for the development of new drugs with potential therapeutic applications.
2. Used in Chemical Synthesis:
1-(2-Chloro-3-fluorophenyl)ethanone serves as a versatile reagent in the chemical synthesis of a wide range of organic compounds. Its presence in the molecule can influence the reactivity and selectivity of various chemical reactions, making it a useful tool in the synthesis of complex organic molecules.
3. Used in the Synthesis of 6-aminofuro[3,2-c]pyridines:
1-(2-Chloro-3-fluorophenyl)ethanone is used as a starting material to prepare novel 6-aminofuro[3,2-c]pyridines, which are potent, orally efficacious inhibitors of cMET and RON kinases. These inhibitors have potential applications in the treatment of various diseases, including cancer, by targeting specific cellular signaling pathways involved in cell growth and proliferation.
Check Digit Verification of cas no
The CAS Registry Mumber 161957-57-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,1,9,5 and 7 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 161957-57:
(8*1)+(7*6)+(6*1)+(5*9)+(4*5)+(3*7)+(2*5)+(1*7)=159
159 % 10 = 9
So 161957-57-9 is a valid CAS Registry Number.
InChI:InChI=1S/C8H6ClFO/c1-5(11)6-3-2-4-7(10)8(6)9/h2-4H,1H3
161957-57-9Relevant articles and documents
Iminothiadiazine Dioxide Compounds as BACE Inhibitors, Compositions and Their Use
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Paragraph 0502, (2015/11/16)
In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): and include stereoisomers thereof, and pharmaceutically acceptable salts of said compounds stereoisomers, wherein each of R1, R2, R3, R4, R5, R9, ring A, ring B, m, n, p, -L1-, -L2-, and -L3- is selected independently and as defined herein. The novel iminothiadiazine dioxide compounds of the invention have surprisingly been found to exhibit properties which are expected to render them advantageous as BACE inhibitors and/or for the treatment and prevention of various pathologies related to β-amyloid (“Aβ”) production. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimer's disease, are also disclosed.
Lithiations directed by carboxylic acid, fluorine and chlorine: The regioselective synthesis of polysubstituted benzoic acids and acetophenones
Moyroud, Joel,Guesnet, Jean-Luc,Bennetau, Bernard,Mortier, Jacques
, p. 133 - 141 (2007/10/03)
Lithiation/electrophilic quenching of ortho-lithiated benzoates allows the totally regiocontrolled synthesis of a wide range of 2,3-, 2,3,4-, and 2,3,4,5-polysubstituted benzoic acids and related acetophenones. Elsevier,.
