1614234-65-9

Basic information

• Product Name: benzyl 4-isopropoxypiperidine-1-carboxylate
• Synonyms: benzyl 4-isopropoxypiperidine-1-carboxylate
• CAS NO: 1614234-65-9
• Molecular Weight: 277.364
• Mol File: 1614234-65-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: benzyl 4-isopropoxypiperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 4-isopropoxypiperidine-1-carboxylate(1614234-65-9)
• EPA Substance Registry System: benzyl 4-isopropoxypiperidine-1-carboxylate(1614234-65-9)

Safety Data

• Hazardous Substances Data: 1614234-65-9(Hazardous Substances Data)

Upstream product

• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 
• 1825-64-5 isopropoxytrimethylsilane 

Downstream Products

• 43139-18-0 4-isopropoxypiperidine 

Relevant articles and documents

A biocatalytic/reductive etherification approach to substituted piperidinyl ethers

A synthetically useful protocol has been developed for the preparation of highly functionalized piperidinyl ethers. Biocatalytic reduction of cyclhexanones 7, 10, and 14 allows for the preparation of both cis- and trans diastereomers with an extremely high degree of stereochemical control. Reductive etherification of the corresponding trimethylsilylethers with 1-(benzyloxycarbonyl)-4-piperidinone 17 in the presence of triethylsilane and catalytic TMSO-Tf provides the desired piperidinyl ethers in good to excellent yields. Finally hygrogenolysis of the nitrogen protecting group leads to piperidinyl ethers in near quantitative yields. Application of the methodology to a range of piperidinyl ethers, including the core scaffolds of diphenylpyraline and ebastine, is also described.