16096-33-6Relevant articles and documents
Hypervalent iodine in synthesis. 77. An efficient method for the synthesis of N-arylindoles by the copper-catalyzed N-arylation of indole with diaryliodonium salts
Zhou, Tao,Chen, Zhen-Chu
, p. 903 - 907 (2002)
N-arylindoles were prepared in good yields by copper-catalyzed N-arylation of indole with diaryliodonium salts.
New polymer-bound haloarene chromium dicarbonyl isocyanide complexes: A successful study validating their use in solid-phase chemistry
Maiorana,Baldoli,Licandro,Casiraghi,De Magistris,Paio,Provera,Seneci
, p. 7271 - 7275 (2000)
New fluorobenzene chromium dicarbonylisocyanide complexes have been synthesized and evaluated in terms of their 'in solution' reactivity towards some nucleophiles. For the first time the polymer-bound isocyanides have been found to be valuable ligands for anchoring haloareneCr(CO)3 complexes by means of their substitution for a CO group. The supported fluorobenzene complex reacted with nitrogen-nucleophiles. (C) 2000 Elsevier Science Ltd.
Hoveyda-Grubbs catalyst analogues bearing the derivatives of: N -phenylpyrrol in the carbene ligand-structure, stability, activity and unique ruthenium-phenyl interactions
Grudzień,Trzaskowski,Smoleń,Gajda,Wo?niak,Grela
, p. 11790 - 11799 (2017)
We have synthesized a series of N-phenylpyrrole and N-phenylindole carbenes and used them as ruthenium-ligating moieties in the synthesis of Hoveyda-Grubbs catalyst derivatives. We show that most of these complexes are difficult to synthesize and unstable apart from the N-phenylpyrrole-2,6-diisopropylphenyl ruthenium complex and its perbrominated derivative. These two systems are almost completely inactive in ring-closing metathesis at room temperature and become active only at 80 °C. DFT, SAPT0 and DLPNO-CCSD(T) calculations suggest that the rarely occurring phenyl-ruthenium interactions are responsible for the very slow initiation of these precatalysts at low temperatures.
Chemical synthesis, spectroscopic studies, chemical reactivity properties and bioactivity scores of an azepin-based molecule
Kollur, Shiva Prasad,Castro, Joaquín Ortega,Frau, Juan,Glossman-Mitnik, Daniel
, p. 300 - 306 (2019)
Azepines derived molecules are of great interest because of their multi-drug like properties and thus advantageous in biomedical field. Herein, a novel route is described for the synthesis of an azepine-based molecule, 10,11-Dibromo-10,11-dihydro- 5H-dibenzo[b,f]azepine-5-carbonyl chloride (DACC) by using dibutyltin dilaurate (DBTDL) as catalyst. The structure of DACC was elucidated by using FT-IR, NMR, and mass spectroscopic techniques. Several density functionals were considered for the study of the molecular properties of the synthesized compound. The global and local reactivity descriptors were estimated by using Conceptual Density Functional Theory (CDFT). The active sites suitable for the nucleophilic and electrophilic attacks were selected by linking them with the Fukui indices, Parr functions and condensed Dual Descriptor Δf(r). Finally, the bioactivity scores for the studied molecule were predicted through different methodologies.
Cu(i) based catalysts derived from bidentate ligands and studies on the effect of substituents for: N -arylation of benzimidazoles and indoles
Kumari, Sheela,Ratnam, Anand,Mawai, Kiran,Chaudhary, Virendra Kumar,Mohanty, Aurobinda,Ghosh, Kaushik
, p. 19591 - 19597 (2020)
A family of Cu(i) complexes [Cu(L1-4)(Cl)(PPh3)] (C1-C4) were synthesized from bidentate ligands L1-L4 (where L1 = (E)-2-(2-benzylidene-1-phenylhydrazinyl)pyridine, L2 = (E)-N,N-dimethyl-4-((2-phenyl-2-(pyridin-2-yl)hydrazono)methyl)aniline, L3 = (E)-2-(2
Aromatic nucleophilic substitution on haloarene chromium tricarbonyl complexes: Mild N-arylation on indoles
Maiorana, Stefano,Baldoli, Clara,Del Buttero, Paola,Di Ciolo, Michela,Papagni, Antonio
, p. 735 - 738 (1998)
A series of N-arylindoles were obtained in good yields and under mild conditions by nucleophilic substitution reaction of the sodium salt of indole on various haloarene chromium tricarbonyl complexes.
SiO2-functionalized melamine-pyridine group–supported Cu(OAc)2 as an efficient heterogeneous and recyclable nanocatalyst for the N-arylation of amines through Ullmann coupling reactions
Hemmati, Saba,Naderi, Akram,Ghadermazi, Mohammad,Veisi, Hojat
, p. 659 - 668 (2018)
This study reports a convenient approach to prepare SiO2/CCPy/Cu(OAc)2 as a novel nanocatalyst, in which melamine-bearing pyridine groups have functionalized SiO2 and can act as a capping agent to stabilize Cu(II) species.
Synthesis and characterization of nano-cellulose immobilized phenanthroline-copper (I) complex as a recyclable and efficient catalyst for preparation of diaryl ethers, N-aryl amides and N-aryl heterocycles
Aghili, Nora,Hosseinzadeh, Rahman,Mavvaji, Mohammad
, (2022/01/03)
Functionalized nanocellulose was prepared and employed for immobilization of phenanthroline-copper(I) complex to afford cellulose nanofibril grafted heterogeneous copper catalyst [CNF-phen-Cu(I)]. This nanocatalyst was well characterized using FT-IR, NMR, XRD, CHNS, AAS, TGA, EDX and SEM. The activities of the synthesized catalyst were examined in the synthesis of diaryl ethers via C-O cross-coupling of phenols and aryl iodides, as well as, the preparation of N-aryl amides and N-aryl heterocycles through C-N cross-coupling of amides and N-H heterocycle compounds with aryl halides. In this trend, various substrates containing electron-donating and electron-withdrawing groups were exploited to evaluate the generality of this catalytic protocol. Accordingly, the catalyst demonstrated remarkable catalytic efficiency for both C-N and C-O cross-coupling reactions, thereby resulting in good to excellent yields of the desired products. Furthermore, the recoverability experiments of the catalyst showed that it can be readily retrieved by simple filtration and successfully reused several times with negligible loss of its catalytic activity.
Manganese(III) Acetate Catalyzed Aerobic Dehydrogenation of Tertiary Indolines, Tetrahydroquinolines and an N-Unsubstituted Indoline
Niu, Xiaokang,Yang, Lei
supporting information, p. 4209 - 4215 (2021/08/06)
A Mn(OAc)3 ? 2H2O-catalyzed aerobic dehydrogenation of five and six-membered N-heterocycles for the synthesis of N-heteroarenes is reported. Of note, this protocol can be applied to the dehydrogenation of tertiary indolines with various electron-deficient N-substituents. Preliminary mechanistic investigations support that a single-electron transfer pathway might be involved. (Figure presented.).
Photocatalyst-Free, Visible-Light-Mediated C(sp3)-H Arylation of Amides via a Solvent-Caged EDA Complex
Kaur, Jaspreet,Shahin, Ahmed,Barham, Joshua P.
supporting information, p. 2002 - 2006 (2021/03/08)
A photocatalyst-free and mild visible light photochemical procedure for C(sp3)-H arylation of amides is described. The reaction proceeds via an electron donor-acceptor (EDA) complex between an electron-rich arene substrate and electron-poor persulfate oxi