15898-38-1

Basic information

• Product Name: 3-Methylbenzenesulfinic acid sodiuM salt
• Synonyms: 3-Methylbenzenesulfinic acid sodiuM salt;3-Methylbenezenesulfinic acid sodium salt
• CAS NO: 15898-38-1
• Molecular Formula: C7H7NaO2S
• Molecular Weight: 178.187
• Mol File: 15898-38-1.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 3-Methylbenzenesulfinic acid sodiuM salt(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methylbenzenesulfinic acid sodiuM salt(15898-38-1)
• EPA Substance Registry System: 3-Methylbenzenesulfinic acid sodiuM salt(15898-38-1)

Safety Data

• Hazardous Substances Data: 15898-38-1(Hazardous Substances Data)

Upstream product

• 1899-93-0 3-methylphenylsulfonyl chloride 
• 17933-03-8 m-tolylboronic acid 

Downstream Products

• 454-66-0 3-methylbenzenesulfonyl fluoride 
• 1175539-76-0 1-methyl-3-(2-methyl-but-3-ene-2-sulfonyl)-benzene 
• 1257390-76-3 1,3,7-trimethyl-8-(3-tolyl)-xanthine 
• 92724-29-3 2‐m‐tolylbenzofuran 
• 173593-27-6 (E)-3-(3-tolyl)acrylic acid n-butyl ester 
• 612-75-9 3,3'-dimethyl-biphenyl 
• 1628709-36-3 2,3-bis-(3-methylbenzene)sulfonylpropene 
• 1899-94-1 3-methylbenzenesulfonamide 
• 643-93-6 3-methylbiphenyl 
• 10355-06-3 methyl 3-methylphenyl sulfone 

Relevant articles and documents

Visible-Light-Driven Sulfonation of α-Trifluoromethylstyrenes: Access to Densely Functionalized CF3-Substituted Tertiary Alcohol

Reported herein is a visible-light-induced sulfonation of α-trifluoromethylstyrenes with sodium sulfinates, which provides a series of α-trifluoromethyl-β-sulfonyl tertiary alcohols. This new synthetic protocol is enabled by a charge-transfer complex between oxygen and sulfinates, featuring broad substrate scope and scalability. Excellent functional group compatibility and chemoselectivity render this method suitable for sulfonation of pharmaceutically relevant molecules. In the presence of D2O, deuteriotrifluorinated products were also obtained, further demonstrating the flexibility and synthetic potentials of this strategy.

Enhancing the Potential of Miniature-Scale DNA-Compatible Radical Reactions via an Electron Donor-Acceptor Complex and a Reversible Adsorption to Solid Support Strategy

DNA-encoded library (DEL) technology is a powerful tool in the discovery of bioactive probe molecules and drug leads. Mostly, the success in DEL technology stems from the molecular diversity of the chemical libraries. However, the construction of DELs has been restricted by the idiosyncratic needs and the required low concentration (～1 mM or less) of the library intermediate. Here, we report visible-light-promoted on-DNA radical coupling reactions via an electron donor-acceptor (EDA) complex and a reversible adsorption to solid support (RASS) strategy. This protocol provides a unique solution to the challenges of increasing the reactivity of highly diluted DNA substrates and reducing the residues of heavy metals from photocatalysts. A series of on-DNA indole sulfone and selenide derivatives were obtained with good to quantitative conversions. It is anticipated that these mild-condition on-DNA radical reactions will significantly improve the chemical diversity of DELs and find widespread utility to DEL construction.

Copper-Catalyzed Enantioselective Construction of Tertiary Propargylic Sulfones

Tertiary propargylic sulfones are of significant importance in organic synthesis and medicinal chemistry, but to date no general asymmetric synthesis approach has been developed. We disclose a versatile copper-catalyzed sulfonylation of propargylic cyclic carbonates using sodium sulfinates that allows the construction of propargylic sulfones featuring elusive quaternary stereocenters. This method provides the first successful example of such an enantioselective propargylic sulfonylation, features high asymmetric induction, wide functional group tolerance, and scalability, and enables attractive product diversification.