15836-66-5Relevant articles and documents
Synthesis of 3-phenylisoindolinones by reaction of 2-carboxybenzophenone and 2-methoxycarbonylbenzophenone with ureas in formic acid
Bakibaev,Yanovskii,Skarlygin
, p. 1209 - 1210 (2003)
-
Tandem C(sp3)?H Arylation/Oxidation and Arylation/Allylic Substitution of Isoindolinones
Jiménez, Jacqueline,Kim, Byeong-Seon,Walsh, Patrick J.
, p. 2829 - 2837 (2016/09/13)
Isoindolinones comprise an important class of medicinally active compounds. Herein we report a straightforward functionalization of isoindolinones with aryl bromides (22 examples) using a palladium(II) acetate/NIXANTPHOS-based catalyst system. Additionally 3-aryl-3-hydroxyisoindolinone derivatives, which exhibit anti-tumor activity, can be accessed via a tandem reaction. Thus, when the arylation product is exposed to air under basic conditions, in situ oxidation takes place to install the 3-hydroxy group. Furthermore, a tandem arylation/allylic substitution reaction is advanced in which both the arylation and allylic substitution are catalyzed by the same palladium catalyst. Finally, a tandem arylation/alkylation procedure is presented. These tandem reactions enable the synthesis of a variety of structurally diverse isoindolinone derivatives from common starting materials. (Figure presented.).
N-Capping of primary amines with 2-Acylbenzaldehydes to give isoindolinones
Augner, Daniel,Gerbino, Dario C.,Slavov, Nikolay,Neudoerfl, Joerg-Martin,Schmalz, Hans-Guenther
supporting information; experimental part, p. 5374 - 5377 (2011/12/03)
A unique reactivity pattern, first observed in the conversion of the marine natural product pestalone into pestalachloride A, was investigated. It was shown that 2-formyl-arylketones smoothly react with ammonia and primary amines, respectively, under mild
