15785-31-6Relevant articles and documents
Enzymatic synthesis of chiral amino acid sulfoxides by Fe(II)/α- ketoglutarate-dependent dioxygenase
Hibi, Makoto,Kawashima, Takashi,Yajima, Hiroko,Smirnov, Sergey V.,Kodera, Tomohiro,Sugiyama, Masakazu,Shimizu, Sakayu,Yokozeki, Kenzo,Ogawa, Jun
, p. 990 - 994 (2013)
Asymmetric sulfoxidation of sulfur-containing l-amino acids was successfully achieved through bioconversion using IDO, which is an Fe(II)/α-ketoglutarate-dependent dioxygenase previously found in Bacillus thuringiensis strain 2e2. The IDO catalyzed sulfoxidation of l-methionine, l-ethionine, S-methyl-l-cysteine, S-ethyl-l-cysteine, and S-allyl-l-cysteine into the corresponding (S)-configured sulfoxides such as (+)-methiin and (+)-alliin, which are responsible for valuable physiological activities in mammals, and have high stereoselectivity. Herein we have established an effective preparative laboratory scale production method to obtain enantiomerically pure chiral sulfoxides using an IDO biocatalyst.
Chloroperoxidase-catalyzed oxidation of methionine derivatives
Holland, Herbert L.,Brown, Frances M.,Lozada, Damian,Mayne, Benjamin,Szerminski, W. Rick,Van Vliet, Aaron J.
, p. 633 - 639 (2007/10/03)
Treatment of N-methoxycarbonyl C-carboxylate ester derivatives of L- and D-methionine and L-ethionine by chloroperoxidase-hydrogen peroxide resulted in oxidation at sulfur to produce the (RS) sulfoxide in moderate to high diastereomeric excess.
