156781-20-3

Basic information

• Product Name: 2-(bis-acetoxymethyl)phenylsulfonyl chloride
• Synonyms: 2-(bis-acetoxymethyl)phenylsulfonyl chloride
• CAS NO: 156781-20-3
• Molecular Weight: 306.724
• Mol File: 156781-20-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(bis-acetoxymethyl)phenylsulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(bis-acetoxymethyl)phenylsulfonyl chloride(156781-20-3)
• EPA Substance Registry System: 2-(bis-acetoxymethyl)phenylsulfonyl chloride(156781-20-3)

Safety Data

• Hazardous Substances Data: 156781-20-3(Hazardous Substances Data)

Upstream product

• 1008-72-6 sodium 2-formylbenzenesulfonate 
• 108-24-7 acetic anhydride 
• 21639-41-8 2-formylbenzene-1-sulfonyl chloride 

Downstream Products

• 156781-24-7 ethyl 4-<2-<2-(3-acetylthiazolidin-2-yl)phenylsulfonylamino>ethyl>phenoxyacetate 
• 156781-23-6 ethyl 4-<2-<2-(thiazolidin-2-yl)phenylsulfonylamino>ethyl>phenoxyacetate 
• 1027477-06-0 S,S-dioxo-2,3-dihydro-3-ethoxy-2-<2-(4-ethoxycarbonylmethoxy)phenyl>benzoisothiazole 
• 156781-21-4 ethyl 4-<2-(bis-acetoxymethylphenylsulfonylamino)ethyl>phenoxyacetate 

Relevant articles and documents

Synthesis and evaluation of novel thiazolidine derivatives as thromboxane A2 receptor antagonists

A series of 3-benzoyl or 3-phenylsulfonyl-2-substituted thiazolidine derivatives were synthesized, and evaluated for their thromboxane A2 (TXA2) receptor-antagonizing effect on (15S)-15-hydroxy-11α,9α- (epoxymethano)prosta-5(Z),13(E)-dienoic acid (U-46619)-induced aggregation of rabbit platelet-rich plasma (PRP). A simple 2-arylthiazolidine derivative, 3- benzoyl-2-(4-hydroxy-3-methoxyphenyl)thiazolidine (5a), showed mild TXA2 receptor antagonist activity. Modification of 5a led to 2-chloro-4-[3-(4- chlorophenylsulfonyl)thiazolidin-2-ylmethyl]phenoxyaretic acid (29d), which showed 10 times more potent TXA2 receptor antagonist activity than 5a.