1547229-23-1

Basic information

• Product Name: (1S,2S)-3-chloro-2-(2,4-difluorophenyl)-1-(5-fluoropyrimidin-4-yl)-2-((trimethylsilyl)oxy)propan-1-ol
• Synonyms: (1S,2S)-3-chloro-2-(2,4-difluorophenyl)-1-(5-fluoropyrimidin-4-yl)-2-((trimethylsilyl)oxy)propan-1-ol
• CAS NO: 1547229-23-1
• Molecular Weight: 390.865
• Mol File: 1547229-23-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1S,2S)-3-chloro-2-(2,4-difluorophenyl)-1-(5-fluoropyrimidin-4-yl)-2-((trimethylsilyl)oxy)propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S)-3-chloro-2-(2,4-difluorophenyl)-1-(5-fluoropyrimidin-4-yl)-2-((trimethylsilyl)oxy)propan-1-ol(1547229-23-1)
• EPA Substance Registry System: (1S,2S)-3-chloro-2-(2,4-difluorophenyl)-1-(5-fluoropyrimidin-4-yl)-2-((trimethylsilyl)oxy)propan-1-ol(1547229-23-1)

Safety Data

• Hazardous Substances Data: 1547229-23-1(Hazardous Substances Data)

Upstream product

• 861718-85-6 3-chloro-2-(2,4-difluorophenyl)-2-(trimethylsilanyloxy)propionaldehyde 
• 1003706-87-3 4-bromo-5-fluoro-pyrimidine 

Relevant articles and documents

COMPOUND AND METHOD FOR MANUFACTURING THE SAME, AND METHOD FOR MANUFACTURING VORICONAZOLE

PROBLEM TO BE SOLVED: To provide a method for manufacturing voriconazole, which is a therapeutic agent for severe or intractable deep mycosis such as aspergillosis, allowing easy manufacture without the need for the optical resolution. SOLUTION: A method for manufacturing voriconazole includes: obtaining a compound represented by the general formula (3) by using catalytic asymmetric cyanoacylation reaction; and reacting the compound with 1,2,4-triazole to convert it into voriconazole. [In the general formula (3), X is any of the divalent groups represented by the specified structural formulas.] COPYRIGHT: (C)2015,JPOandINPIT