154421-63-3Relevant articles and documents
Cyclocondensation of 2-(3-thienyl)substituted O-alkyl glycolohydroxamic acids to 5,6-dihydro-6aH-thieno[2,3-b]pyrrol-5-ones
Geffken,Groll
, p. 801 - 806 (2007/10/02)
Dicyclohexylcarbodiimide converts the O-alkyl glycolohydroxamic acids 4A, 4B into 5,6-dihydro-6aH-thieno[2,3-b]pyrrol-5-ones 6A, 6B, the formation of which depends on the nature of the C2-substituents. Acid-catalyzed methanolysis of 6Ba, c, e affords the cyclic hydroxamic acids 9a-c that can be reduced by titanium chloride to 8. Addition of phenylisocyanate to 9a gives smoothly 10 and compound 11 arises from alkylation of 9b with tert-butyl bromoacetate.