153923-41-2

Basic information

• Product Name: (S)-2-[ (tert-butoxycarbonyl)-amino]-3-(4-methoxyphenyl)-propylmethanesulfonate
• Synonyms: (S)-2-[ (tert-butoxycarbonyl)-amino]-3-(4-methoxyphenyl)-propylmethanesulfonate
• CAS NO: 153923-41-2
• Molecular Weight: 359.444
• Mol File: 153923-41-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-2-[ (tert-butoxycarbonyl)-amino]-3-(4-methoxyphenyl)-propylmethanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-[ (tert-butoxycarbonyl)-amino]-3-(4-methoxyphenyl)-propylmethanesulfonate(153923-41-2)
• EPA Substance Registry System: (S)-2-[ (tert-butoxycarbonyl)-amino]-3-(4-methoxyphenyl)-propylmethanesulfonate(153923-41-2)

Safety Data

• Hazardous Substances Data: 153923-41-2(Hazardous Substances Data)

Upstream product

• 53267-93-9 O-methyl-N-tert-butoxycarbonyl-L-tyrosine 
• 124-63-0 methanesulfonyl chloride 
• 126395-29-7 [(S)-2-hydroxy-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester 

Downstream Products

• 167421-95-6 [(S)-1-Ethylsulfanylmethyl-2-(4-methoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 443149-93-7 (3R)-3-[2-acetylamino-(1S)-1-(4-methoxybenzyl)ethylcarbamoyl]-5-methylhexanoic acid tert butyl ester 
• 443150-03-6 (3R)-3-[2-acetylamino-(1S)-1-(4-methoxybenzyl)ethylcarbamoyl]-5-methylhexanoic acid 
• 443150-01-4 N-(2S)-2-[(tert-butoxycarbonylamino)-3-(4-methoxyphenyl)propyl]acetamide 
• 443149-91-5 N-[(1S)-2-azido-1-(4-methoxyphenylmethyl)ethyl](tert-butoxy)carboxamide 

Relevant articles and documents

UREA DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF

The present invention provides a urea compound or a pharmacologically acceptable salt thereof that has a formyl peptide receptor like 1 (hereinafter may be abbreviated as FPRL1) agonist effect, a pharmaceutical composition containing the urea compound or the pharmacologically acceptable salt thereof, and a pharmaceutical use thereof. It has been found that a urea derivative represented by the general formula (I) below or a pharmacologically acceptable salt thereof has a superior FPRL1 agonist effect. Compound (I) or a pharmacologically acceptable salt thereof is highly useful for treatment, prevention, or suppression of inflammatory diseases, chronic airway diseases, cancers, septicemia, allergic symptoms, HIV retrovirus infection, circulatory disorders, neuroinflammation, nervous disorders, pains, prion diseases, amyloidosis, immune disorders and the like.

Conversion of chiral amino acids to enantiomerically pure α-methylamines

Enantiomerically enriched α-methylamines are obtained in high yield by Raney nickel reduction of N-Boc-protected, amino acid-derived thioethers.