153708-38-4Relevant articles and documents
Self-reproduction of chirality. Asymmetric synthesis of β-alkyl-β-amino acids from enantiomerically pure dihydropyrimidinones
Chu, Kent S.,Konopelski, Joseph P.
, p. 9183 - 9190 (2007/10/02)
Enantiomerically pure heterocycle 2 is deprotonated at C6 with tert-butyllithium at -78°C. The resulting carbanion reacts with alkyl halides and aldehydes to give the corresponding alkylated products. Reduction of the double bond followed by hydrolysis affords enantiomerically pure β-alkyl-β-amino acids.
