153436-53-4 Usage
Description
AG 1478 hydrochloride, also known as an epidermal growth factor receptor tyrosine kinase inhibitor, is a potent and specific inhibitor with an IC50 of 3 nM. It is a small molecule compound that plays a crucial role in the regulation of cell growth and differentiation by targeting the EGFR pathway.
Uses
Used in Pharmaceutical Industry:
AG 1478 hydrochloride is used as a pharmaceutical agent for inhibiting the epidermal growth factor receptor (EGFR) tyrosine kinase activity. This inhibition helps in the treatment of various cancers by blocking the signaling pathways that promote cell proliferation and survival.
Used in Cancer Research:
AG 1478 hydrochloride is used as a research tool for studying the role of EGFR in cancer cell growth and progression. It aids in understanding the molecular mechanisms underlying the development of cancer and the potential of EGFR inhibition as a therapeutic strategy.
Used in Drug Development:
AG 1478 hydrochloride is used as a lead compound in the development of novel EGFR inhibitors. Its potent and specific inhibition of EGFR tyrosine kinase activity makes it a valuable starting point for the design and synthesis of new drugs targeting this important cellular pathway.
Used in Cell Signaling Studies:
AG 1478 hydrochloride is used as a biochemical reagent for investigating the role of EGFR in cell signaling processes. By inhibiting EGFR activity, researchers can gain insights into the complex network of signaling pathways that regulate cell behavior and contribute to the development of various diseases, including cancer.
Biological Activity
Potent and selective inhibitor of epidermal growth factor receptor kinase (IC 50 values 3 nM for EGFR and > 100 μ M for ErbB2 and PDGFR). Inhibits proliferation of NCI-H2170 NSCLC cells in vitro (IC 50 = 1 μ M).
Check Digit Verification of cas no
The CAS Registry Mumber 153436-53-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,3,4,3 and 6 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 153436-53:
(8*1)+(7*5)+(6*3)+(5*4)+(4*3)+(3*6)+(2*5)+(1*3)=124
124 % 10 = 4
So 153436-53-4 is a valid CAS Registry Number.
153436-53-4Relevant articles and documents
Novel dual use of formamide-POCl3 mixture for the efficient, one-pot synthesis of condensed 2 H-pyrimidin-4-amine libraries under microwave irradiation
Jain, Kishore S.,Kathiravan, Muthu K.,Bariwal, Jitender B.,Chaskar, Pratip K.,Tompe, Santosh S.,Arya, Nikhilesh
, p. 719 - 727 (2013/01/15)
The novel dual use of formamide-POCl3 mixture for the incorporation of a C-N fragment to form the pyrimidine nucleus and its subsequent chlorination in an efficient, one-pot synthesis of potentially bioactive condensed 2H-pyrimidin-4-amine libraries under
