153435-80-4

Basic information

• Product Name: 3-BROMO,N, N-DIMETHYLBENZENESULFONAMIDE
• Synonyms: N,N-DIMETHYL 3-BROMOBENZENESULFONAMIDE;3-BROMO,N, N-DIMETHYLBENZENESULFONAMIDE;3-BROMO-N,N-DIMETHYLBENZENESULPHONAMIDE;3-Bromo-N,N-dimethylbenzenesulphonamide 98%;N,N-Dimethyl 3-bromophenylsulfonamide;3-Bromo-N,N-dimethylbenzenesulphonamide98%
• CAS NO: 153435-80-4
• Molecular Formula: C₈H₁₀BrNO₂S
• Molecular Weight: 264.14
• Product Categories: blocks;Bromides;Sulfonamides;Aryl;Organohalides;Sulfonamide;alkyl bromide
• Mol File: 153435-80-4.mol
• Article Data: 9

Chemical Properties

• Melting Point: 74-78
• Boiling Point: 340.3 °C at 760 mmHg
• Flash Point: 159.6 °C
• Appearance: /
• Density: 1.543 g/cm³
• Vapor Pressure: 8.66E-05mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: 3-BROMO,N, N-DIMETHYLBENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO,N, N-DIMETHYLBENZENESULFONAMIDE(153435-80-4)
• EPA Substance Registry System: 3-BROMO,N, N-DIMETHYLBENZENESULFONAMIDE(153435-80-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 153435-80-4(Hazardous Substances Data)

Usage

General Description

3-Bromo-N,N-dimethylbenzenesulfonamide is a chemical compound with the molecular formula C8H10BrNO2S. It is used as a mildewcide and fungicide in industrial and agricultural applications. 3-BROMO,N, N-DIMETHYLBENZENESULFONAMIDE is a white to off-white crystalline solid with a slightly sulfurous odor and is soluble in water. 3-Bromo-N,N-dimethylbenzenesulfonamide is effective in controlling various types of mold and is also used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It is important to handle this chemical with care as it can be harmful if ingested or inhaled, and can cause skin and eye irritation.

InChI:InChI=1/C8H10BrNO2S/c1-10(2)13(11,12)8-5-3-4-7(9)6-8/h3-6H,1-2H3

Upstream product

• 153435-79-1 N-methyl-3-bromobenzenesulfonamide 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 2905-24-0 3-Bromobenzenesulfonyl chloride 
• 506-59-2 N,N-dimethylammonium chloride 
• 124-40-3 dimethyl amine 

Downstream Products

• 153435-33-7 N,N-dimethyl-3-tributylstannylbenzenesulfonamide 
• 486422-05-3 N,N-dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide 
• 1240285-86-2 {4-chloro-2-[(3-dimethylaminosulfonylphenyl)ethynyl]phenoxy}acetic acid 
• 288571-54-0 3-[3-(2-methoxymethylene-cyclohexyl)-propionyl]-N,N-dimethyl-benzenesulfonamide 
• 452340-00-0 3-[4-({6-[(5R)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-oxo-1,3-oxazolidin-3-yl]hexyl}oxy)but-1-ynyl]-N,N-dimethylbenzenesulfonamide 

Relevant articles and documents

Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics**

Protein arginine N-methyl transferase 4 (PRMT4) asymmetrically dimethylates the arginine residues of histone H3 and nonhistone proteins. The overexpression of PRMT4 in several cancers has stimulated interest in the discovery of inhibitors as biological tools and, potentially, therapeutics. Although several PRMT4 inhibitors have been reported, most display poor selectivity against other members of the PRMT family of methyl transferases. Herein, we report the structure-based design of a new class of alanine-containing 3-arylindoles as potent and selective PRMT4 inhibitors, and describe key structure–activity relationships for this class of compounds.

Structure-activity relationship studies for the development of inhibitors of murine adipose triglyceride lipase (ATGL)

High serum fatty acid (FA) levels are causally linked to the development of insulin resistance, which eventually progresses to type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) generalized in the term metabolic syndrome. Adipose triglyceride lipase (ATGL) is the initial enzyme in the hydrolysis of intracellular triacylglycerol (TG) stores, liberating fatty acids that are released from adipocytes into the circulation. Hence, ATGL-specific inhibitors have the potential to lower circulating FA concentrations, and counteract the development of insulin resistance and NAFLD. In this article, we report about structure–activity relationship (SAR) studies of small molecule inhibitors of murine ATGL which led to the development of Atglistatin. Atglistatin is a specific inhibitor of murine ATGL, which has proven useful for the validation of ATGL as a potential drug target.

Selective methylation of NH-containing heterocycles and sulfonamides using n, N -dimethylformamide dimethylacetal based on calculated pKa Measurements

The use of N,N-dimethylformamide dimethylacetal (DMF-DMA) as a suitable methylating agent for the methylation of NH-containing groups and heterocycles has been investigated. Use of ReactArray and calculated pKa measurements have allowed additional helpful information to be collated to determine optimum reaction conditions for a variety of substrates.