152965-58-7

Basic information

• Product Name: 2-amino-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-6-(methylthio)purine
• Synonyms: 2-amino-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-6-(methylthio)purine
• CAS NO: 152965-58-7
• Molecular Weight: 533.608
• Mol File: 152965-58-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-amino-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-6-(methylthio)purine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-6-(methylthio)purine(152965-58-7)
• EPA Substance Registry System: 2-amino-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-6-(methylthio)purine(152965-58-7)

Safety Data

• Hazardous Substances Data: 152965-58-7(Hazardous Substances Data)

Upstream product

• 4330-21-6 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride 
• 1198-47-6 2-amino-6-(methylsulfanyl)purine 

Downstream Products

• 37113-42-1 2'-deoxy-6-methylthioguanosine 

Relevant articles and documents

6-Substituted 2-Aminopurine-2′-deoxyribonucleoside 5′-Triphosphates that Trace Cytosine Methylation

Gene expression is extensively regulated by the occurrence and distribution of the epigenetic marker 2′-deoxy 5-methylcytosine (5mC) in genomic DNA. Because of its effects on tumorigenesis there is an important link to human health. In addition, detection of 5mC can serve as an outstanding biomarker for diagnostics as well as for disease therapy. Our previous studies have already shown that, by processing O6-alkylated 2′-deoxyguanosine triphosphate (dGTP) analogues, DNA polymerases are able to sense the presence of a single 5mC unit in a template. Here we present the synthesis and evaluation of an extended toolbox of 6-substituted 2-aminopurine-2′-deoxyribonucleoside 5′-triphosphates modified at position 6 with various functionalities. We found that sensing of 5-methylation by this class of nucleotides is more general, not being restricted to O6-alkyl modification of dGTP but also applying to other functionalities.