1527490-64-7

Basic information

• Product Name: 4-BroMo-5-Methoxy-2-nitro-benzoic acid
• Synonyms: 4-BroMo-5-Methoxy-2-nitro-benzoic acid
• CAS NO: 1527490-64-7
• Molecular Formula: C8H6BrNO5
• Molecular Weight: 276.04094
• Mol File: 1527490-64-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-BroMo-5-Methoxy-2-nitro-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BroMo-5-Methoxy-2-nitro-benzoic acid(1527490-64-7)
• EPA Substance Registry System: 4-BroMo-5-Methoxy-2-nitro-benzoic acid(1527490-64-7)

Safety Data

• Hazardous Substances Data: 1527490-64-7(Hazardous Substances Data)

Usage

General Description

4-Bromo-5-methoxy-2-nitro-benzoic acid is an organic compound with the chemical formula C8H6BrNO6. It is a derivative of benzoic acid and contains bromine, methoxy, and nitro functional groups. 4-BroMo-5-Methoxy-2-nitro-benzoic acid is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and biologically active molecules. It has also been studied for its potential anti-inflammatory and analgesic properties. Additionally, it has been utilized in the development of new materials and as a reagent in organic chemistry reactions. Overall, 4-bromo-5-methoxy-2-nitro-benzoic acid has a range of potential applications in medicinal and chemical research.

Upstream product

• 67-56-1 methanol 
• 1020717-99-0 4-bromo-5-fluoro-2-nitrobenzoic acid 
• 1220886-29-2 methyl 4-bromo-5-fluoro-2-nitrobenzoate 
• 1196664-96-6 4-bromo-5-methoxy-2-nitrobenzaldehyde 
• 861076-28-0 1-bromo-2-methoxy-4-methyl-5-nitrobenzene 
• 224185-19-7 3-bromo-4-fluoro-6-methylnitrobenzene 
• 452-74-4 4-bromo-3-fluorotoluene 

Downstream Products

• 1256955-36-8 methyl 2-amino-4-bromo-5-methoxybenzoate 
• 1623120-79-5 2-amino-4-bromo-5-methoxybenzoic acid 

Relevant articles and documents

Spiro-substituted pyrimido-cyclic compound, and preparation method and medical application thereof

The invention discloses a spiro-substituted pyrimido-cyclic compound with selective inhibition effect on KRAS gene mutation and a pharmaceutically acceptable salt, a stereoisomer, a solvent compound or a prodrug thereof; the spiro-substituted pyrimido-cyclic compound is represented by a formula (I), and the definition of each group or symbol in the formula is shown in the specification in detail.In addition, the invention also discloses a pharmaceutical composition containing the compound and an application of the compound in preparation of cancer drugs.

INHIBITORS OF KRAS G12C

Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, tautomer, prodrug or stereoisomer thereof, wherein R1, R2a, R3a, R3b, R4a, R4b, G1, G2, L1, L2, m1, m2, A, B, W, X, Y, Z and E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.