15182-92-0 Usage
Description
4-[2-(DIMETHYLAMINO)ETHOXY]BENZALDEHYDE is an organic compound with the molecular formula C11H15NO2. It is characterized by its aldehyde group and a dimethylaminoethoxy substituent attached to the benzene ring. 4-[2-(DIMETHYLAMINO)ETHOXY]BENZALDEHYDE is known for its potential applications in the pharmaceutical and chemical industries due to its unique structural features.
Uses
Used in Pharmaceutical Industry:
4-[2-(DIMETHYLAMINO)ETHOXY]BENZALDEHYDE is used as a key intermediate in the synthesis of cyclosporin A analogs, which are NTCP inhibitors. These analogs have potential applications in the treatment of various diseases, including autoimmune disorders and transplant rejection, by modulating the immune system.
In the preparation of cyclosporin A analogs, 4-[2-(DIMETHYLAMINO)ETHOXY]BENZALDEHYDE plays a crucial role in the development of new drugs with improved efficacy and reduced side effects. Its unique structure allows for the creation of molecules that can specifically target NTCP, a protein involved in the transport of bile acids and other substances, thus offering a novel approach to treating related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 15182-92-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,1,8 and 2 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 15182-92:
(7*1)+(6*5)+(5*1)+(4*8)+(3*2)+(2*9)+(1*2)=100
100 % 10 = 0
So 15182-92-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H15NO2/c1-12(2)7-8-14-11-5-3-10(9-13)4-6-11/h3-6,9H,7-8H2,1-2H3
15182-92-0Relevant articles and documents
4-PHENYL-N-(PHENYL)THIAZOL-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS
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Paragraph 00221; 00263, (2021/06/26)
4-phenyl-N-(phenyl)thiazol-2-amine and 4-(pyridin-3-yl)-N-( phenyl) thiazol-2-amine derivatives and the corresponding thiadiazole, thiophene, oxazole, oxadiazole, imidazole and triazole derivatives and related compounds as aryl hydrocarbon receptor (AHR) agonists for the treatment of angiogenesis implicated disorders, such as e.g. retinopathy, psoriasis, rheumatoid arthritis, obesity and cancer, or inflammatory disorders.
Overcoming inaccessibility of fluorinated imines-synthesis of functionalized amines from readily available fluoroacetamides
Czerwiński, Pawe? J.,Furman, Bart?omiej
supporting information, p. 9436 - 9439 (2019/08/15)
Although imines are convenient substrates for the synthesis of functionalized amines, they may be hard to obtain, as in the case of fluorinated imines. To aid in overcoming this issue, we propose a protocol of corresponding amine synthesis from simple fluoroacetic acid-derived amides using Schwartz's reagent.
HETEROARYL INHIBITORS OF PAD4
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Paragraph 00323-00324, (2018/03/28)
The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.