15119-62-7 Usage
Description
4-Nitrophenylthiol acetate is a synthetic compound commonly utilized as a substrate for the enzymatic activity assay of carboxylesterases, particularly in the context of intestinal mucosa. It is characterized by its ability to undergo hydrolysis when acted upon by carboxylesterase enzymes, resulting in the release of 4-nitrophenol, which can be easily detected and quantified.
Uses
Used in Pharmaceutical Research:
4-Nitrophenylthiol acetate is used as a substrate for studying the hydrolysis activity of carboxylesterase enzymes in the intestinal mucosa. This application is crucial for understanding the role of these enzymes in drug metabolism and absorption, as well as their potential involvement in various physiological and pathological processes.
Used in Enzyme Assay Development:
4-Nitrophenylthiol acetate is employed as a colorimetric substrate in the development of enzyme assays, specifically for carboxylesterases. The hydrolysis of this compound by the enzyme of interest results in the release of 4-nitrophenol, which can be monitored spectrophotometrically, providing a quantitative measure of enzyme activity.
Used in Drug Metabolism Studies:
In the field of drug metabolism, 4-nitrophenylthiol acetate is used as a model compound to investigate the hydrolytic capabilities of carboxylesterase enzymes present in the intestinal mucosa. This information is valuable for predicting the bioavailability and efficacy of certain drugs, as well as for designing prodrugs that can be activated by these enzymes.
Used in Toxicology and Environmental Research:
4-Nitrophenylthiol acetate can also be used in toxicology and environmental research to study the potential effects of environmental pollutants and toxins on carboxylesterase activity in the intestinal mucosa. This can help in understanding the mechanisms of toxicity and developing strategies for detoxification and risk assessment.
Hazard
Moderately toxic by ingestion.
Safety Profile
Moderately toxic by ingestion.When heated to decomposition it emits toxic vapors ofNOx and SOx
Check Digit Verification of cas no
The CAS Registry Mumber 15119-62-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,1,1 and 9 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 15119-62:
(7*1)+(6*5)+(5*1)+(4*1)+(3*9)+(2*6)+(1*2)=87
87 % 10 = 7
So 15119-62-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H7NO3S/c1-6(10)13-8-4-2-7(3-5-8)9(11)12/h2-5H,1H3
15119-62-7Relevant articles and documents
Frankfater,Kezdy
, p. 4039,4040 (1971)
Acyl transfer reactions of carbohydrates, alcohols, phenols, thiols and thiophenols under green reaction conditions
Giri, Santosh Kumar,Kartha, K. P. Ravindranathan
, p. 11687 - 11696 (2015/02/19)
Acyl transfer reactions of various carbohydrates, alcohols, phenols, thiols and thiophenols were achieved at room temperature in high yields and catalytic efficiency in the presence of methane sulfonic acid, a green organic acid, under solvent-free conditions over short time periods. The method is mild enough to allow acid labile substituents such as isopropylidene acetals and trityl ethers on the reacting substrates to be left completely unaffected. Esterification of free mono- and dicarboxylic acids such as acetic acid, cinnamic acid, sialic acid and tartaric acid with alcohols such as menthol, ethanol, methanol or propylene glycol has also been achieved efficiently at room temperature. A comparative study of the method with the silica-sulfuric acid is also reported.
Efficient Cu-catalyzed base-free C-S coupling under conventional and microwave heating. A simple access to S-heterocycles and sulfides
Soria-Castro, Silvia M.,Penenory, Alicia B.
supporting information, p. 467 - 475 (2013/05/08)
S-aryl thioacetates can be prepared by reaction of inexpensive potassium thioacetate with both electron-rich and electron-poor aryl iodides under a base-free copper/ligand catalytic system. CuI as copper source affords S-aryl thioacetates in good to excellent yields, by using 1,10-phenanthroline as a ligand in toluene at 100°C after 24 h. Under microwave irradiation the time was drastically reduced to 2 h. Both procedures are simple and involve a low-cost catalytic system. This methodology was also applied to the "one-pot" synthesis of target heterocycles, such as 3H-benzo[c][1,2]dithiol-3-one and 2-methylbenzothiazole, alkyl aryl sulfides, diaryl disulfides and asymmetric diaryl sulfides in good yields.
