149709-61-5

Basic information

• Product Name: (2S,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid ethyl ester
• Synonyms: (2S,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid ethyl ester
• CAS NO: 149709-61-5
• Molecular Weight: 411.541
• Mol File: 149709-61-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2S,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid ethyl ester(149709-61-5)
• EPA Substance Registry System: (2S,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid ethyl ester(149709-61-5)

Safety Data

• Hazardous Substances Data: 149709-61-5(Hazardous Substances Data)

Upstream product

• 1012341-54-6 (2R/S,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid 
• 75-03-6 ethyl iodide 
• 1174131-30-6 (R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylenepentandic acid ethyl ester 
• 98-80-6 phenylboronic acid 
• 70642-86-3 N-(tert-butoxycarbonyl)-D-tyrosine 
• 929872-80-0 tert-butyl (R)-3-(4-hydroxyphenyl)-1-[methoxy(methyl)amino]-1-oxopropan-2-ylcarbamate 
• 1038924-77-4 (S)-2-biphenyl-4-ylmethyl-5-oxopyrrolidine-1-carboxylic acid tert-butyl ester 
• 153037-44-6 (S)-5-biphenyl-4-yl-4-tert-butoxycarbonylaminopentanoic acid ethyl ester 
• 74-88-4 methyl iodide 

Downstream Products

• 1012341-50-2 (2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid 

Relevant articles and documents

BIPHENYL-SUBSTITUED 4-AMINO-BUTYRIC ACID DERIVATIVES AND THEIR USE IN THE SYNTHESIS OF NEP INHIBITORS

The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors and prodrugs thereof.

NEW PROCESSES

The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.