148969-14-6

Basic information

• Product Name: 2'-benzyloxycarbonyl-7-epi-taxol
• Synonyms: 2'-benzyloxycarbonyl-7-epi-taxol
• CAS NO: 148969-14-6
• Molecular Weight: 988.055
• Mol File: 148969-14-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2'-benzyloxycarbonyl-7-epi-taxol(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-benzyloxycarbonyl-7-epi-taxol(148969-14-6)
• EPA Substance Registry System: 2'-benzyloxycarbonyl-7-epi-taxol(148969-14-6)

Safety Data

• Hazardous Substances Data: 148969-14-6(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 105454-04-4 7-epipaclitaxel 
• 33069-62-4 taxol 
• 27548-93-2 baccatin III 

Relevant articles and documents

THE CHEMISTRY OF TAXANES: REACTIONS OF TAXOL AND BACCATIN DERIVATIVES WITH LEWIS ACIDS IN APROTIC AND PROTIC MEDIA

Several Lewis acids were shown to cleanyl open the oxetane ring of taxol and baccatin derivatives.The reaction is shown to proceed via anchimeric assistance by the C-4 acetate group.Several minor products, including a novel derivative possessing a bridged C-ring, were also isolated.A mechanistric rationale is provides for all compounds formed.When taxol derivatives were treated with Lewis acids in methanol, ester cleavage reactions were observed.We provide conditions that are selective for C-10 acetate cleavage and for C-13 side-chain methanolysis.