1483-01-8 Usage
Description
L(+)-Homoarginine hydrochloride, also known as L-Homoarginine, is a non-essential amino acid that serves as an uncompetitive and organ-specific inhibitor of alkaline phosphatases. It is a white powder and is an analog of Homoarginine (H585000). L(+)-Homoarginine hydrochloride has the ability to inhibit human bone and liver alkaline phosphatases without affecting placental or intestinal isoenzymes. L(+)-Homoarginine hydrochloride also plays a role in protein function and structural elucidation by replacing arginine residues, which are often found at the active centers of proteins and enzymes.
Uses
1. Used in Pharmaceutical Industry:
L(+)-Homoarginine hydrochloride is used as an inhibitor of alkaline phosphatase isoenzymes for its ability to inhibit human bone and liver alkaline phosphatases specifically. This makes it a valuable compound for studying and potentially treating conditions related to these enzymes.
2. Used in Cellular Transport Research:
L(+)-Homoarginine hydrochloride is used as an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter. This application aids in understanding the role of arginine transport in cellular processes and its potential implications in various diseases.
3. Used in Protein Function and Structural Studies:
L(+)-Homoarginine hydrochloride is used as a substitute for arginine or lysine in proteins to render them resistant to proteolysis by trypsin. This substitution helps researchers elucidate protein function and structural requirements, contributing to the development of new therapeutic strategies.
4. Used in Cancer Research:
L(+)-Homoarginine hydrochloride is used in cancer research to inhibit proliferation of specific cancer cell lines, such as mouse myeloma MOPC 104E cells and C3H/He mouse osteosarcoma cells. Pre-treatment with L(+)-Homoarginine hydrochloride has been shown to delay in vivo tumor growth in a murine C3H/He osteosarcoma model, making it a potential candidate for further investigation in cancer treatment.
5. Used in Pancreatic Research:
L(+)-Homoarginine hydrochloride is used to inhibit high-protein diet-induced pancreatic growth and enzyme secretion in bile-pancreatic juice-diverted rats, a model for the induction of pancreatic enzyme secretion with hypercholecystokininemia. This application helps researchers understand the role of L(+)-Homoarginine hydrochloride in pancreatic function and its potential implications in pancreatic diseases.
Biochem/physiol Actions
Homoarginine is an inhibitor of tissue nonspecific alkaline phosphatase (TNALP). It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter.
Check Digit Verification of cas no
The CAS Registry Mumber 1483-01-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,8 and 3 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1483-01:
(6*1)+(5*4)+(4*8)+(3*3)+(2*0)+(1*1)=68
68 % 10 = 8
So 1483-01-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H16N4O2.ClH/c8-5(6(12)13)3-1-2-4-11-7(9)10;/h5H,1-4,8H2,(H,12,13)(H4,9,10,11);1H
