14807-96-6 Usage
Description
Talc is a mineral composed of hydrated magnesium silicate with the chemical formula H2Mg3(SiO3)4 or Mg3Si4O10(OH)2. It is an odorless, white to grayish-white, very fine crystalline powder that is unctuous, readily adheres to the skin, and is nonflammable, noncombustible, and nontoxic. Talc is fairly hydrophobic, although treatments are used to enhance its texture.
Uses
Used in Paper Making Industry:
Talc is used as a filler for paper to improve its quality and appearance.
Used in Plastic Industry:
Talc is used as a filler in the plastic industry to enhance the properties of the plastic materials.
Used in Paint and Coatings Industry:
Talc is used as a pigment in paints, varnishes, and coatings to provide a smooth and even finish.
Used in Rubber Industry:
Talc is used as a filler in the rubber industry to improve the physical properties of rubber products.
Used in Food Industry:
Talc is used in the food industry for various applications, such as an anti-caking agent.
Used in Electric Cable Industry:
Talc is used as an insulator in the electric cable industry to enhance the performance of cables.
Used in Pharmaceutical Industry:
Talc is used as an excipient and filler for pills and tablets, as well as for dusting tablet molds.
Used in Cosmetics Industry:
Talc is used in cosmetics as a dusting powder, bulking and opacifying agent, and as an absorbent in makeup preparations. It adds softness and sliding ability to cosmetic formulations.
Used in Medical and Toilet Preparations:
Talc is used as a dusting powder, either alone or with starch or boric acid, for medicinal and toilet preparations.
Used in Clarifying Liquids:
Talc is used as a filtering agent to clarify liquids.
Used in Fireproof and Cold-Water Paints:
Talc is used in fireproof and cold-water paints for wood, metal, and stone to enhance their protective properties.
Used in Lubricating Molds and Machinery:
Talc is used as a lubricant for molds and machinery to reduce friction and wear.
Used in Insulation:
Talc is used as an electric and heat insulator due to its non-conductive properties.
Used in Soapstone:
Talc is a primary component of soapstone, which has been used for carving and as a building material for thousands of years.
History
Talc, soapstone, and steatite have been used by humans as raw materials since prehistoric times. Molds carved from soapstone were used in the Bronze Age and early Iron Age for casting weapons and tools. In the Mediterranean cultures of the classical period, stone carvings were made from soapstone, and talc was used for treating wounds and in the production of cosmetic powder. In ancient Rome, women used large amounts of powder and rouge. The properties of talc, especially its characteristic greasy feel, were described by Pliny the Elder. The old Arabic word talq, which indicates its greasy nature, gave its name to the mineral. In 1550, Catherin de Medici made it once again fashionable to use facial makeup in the form of powdered talc colored by the addition of pigments, a fashion that found innumerable imitators and has continued without interruption until today.
Production Methods
Talc is a naturally occurring hydropolysilicate mineral found in
many parts of the world including Australia, China, Italy, India,
France, and the USA.
The purity of talc varies depending on the country of origin. For
example, Italian types are reported to contain calcium silicate as the
contaminant; Indian types contain aluminum and iron oxides;
French types contain aluminum oxide; and American types contain
calcium carbonate (California), iron oxide (Montana), aluminum and iron oxides (North Carolina), or aluminum oxide (Alabama).
Naturally occurring talc is mined and pulverized before being
subjected to flotation processes to remove various impurities such as
asbestos (tremolite); carbon; dolomite; iron oxide; and various
other magnesium and carbonate minerals. Following this process,
the talc is finely powdered, treated with dilute hydrochloric acid,
washed with water, and then dried. The processing variables of
agglomerated talc strongly influence its physical characteristics.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Talc has low reactivity.
Health Hazard
Pure talc is toxicologically harmless. However, where there are high concentrations of dust in the air, face masks should be worn. If the talc contains detectable amounts of asbestos or asbestos minerals, an MAK value of 2.0 mg/m3 applies. Talc is a nontoxic, inert substance or raw material, but it can contaminate wounds and if inhaled it can cause lung irritations.
Fire Hazard
Literature sources indicate that Talc is nonflammable.
Flammability and Explosibility
Notclassified
Pharmaceutical Applications
Talc was once widely used in oral solid dosage formulations as a
lubricant and diluent, although today it is less
commonly used. However, it is widely used as a dissolution
retardant in the development of controlled-release products. Talc is also used as a lubricant in tablet formulations; in a novel
powder coating for extended-release pellets; and as an adsorbant.
In topical preparations, talc is used as a dusting powder,
although it should not be used to dust surgical gloves. Talc is a natural material; it may therefore frequently contain
microorganisms and should be sterilized when used as a dusting
powder.
Talc is additionally used to clarify liquids and is also used in
cosmetics and food products, mainly for its lubricant properties.
Safety Profile
The talc with less than 1 percent asbestos is regarded as a nuisance dust. Talc with greater percentage of asbestos may be a human carcinogen. A human skin irritant. Prolonged or repeated exposure can produce a form of pulmonary fibrosis (talc pneumoconiosis) which may be due to asbestos content. Questionable carcinogen with experimental tumorigenic data. A common air contaminant.
Safety
Talc is used mainly in tablet and capsule formulations. Talc is not
absorbed systemically following oral ingestion and is therefore
regarded as an essentially nontoxic material. However, intranasal or
intravenous abuse of products containing talc can cause granulomas
in body tissues, particularly the lungs. Contamination of
wounds or body cavities with talc may also cause granulomas;
therefore, it should not be used to dust surgical gloves. Inhalation of
talc causes irritation and may cause severe respiratory distress in
infants.
Although talc has been extensively investigated for its carcinogenic
potential, and it has been suggested that there is an increased
risk of ovarian cancer in women using talc, the evidence is
inconclusive. However, talc contaminated with asbestos has
been proved to be carcinogenic in humans, and asbestos-free grades
should therefore be used in pharmaceutical products.
Also, long-term toxic effects of talc contaminated with large
quantities of hexachlorophene caused serious irreversible neurotoxicity
in infants accidentally exposed to the substance.
Carcinogenicity
In vitro assay of a number of respirable
talc specimens of high purity demonstrated
a modest but consistent cytotoxicity to
macrophages; the investigators conclude that
the talcs would be expected to be slightly fibrogenic
in vivo.
storage
Talc is a stable material and may be sterilized by heating at 160°C
for not less than 1 hour. It may also be sterilized by exposure to
ethylene oxide or gamma irradiation.
Talc should be stored in a well-closed container in a cool, dry
place.
Toxicity evaluation
The mechanism by which the talc is toxic is largely physical in
its function, impairing organ function by inhibiting necessary
movement or transfer of material. Pulmonary responses can
occur through production of microemboli and granuloma
formation.
Incompatibilities
Incompatible with quaternary ammonium compounds.
Regulatory Status
Accepted for use as a food additive in Europe. Included in the FDA
Inactive Ingredients Database (buccal tablets; oral capsules and
tablets; rectal and topical preparations). Included in nonparenteral
medicines licensed in the UK. Included in the Canadian List of
Acceptable Non-medicinal Ingredients.
Check Digit Verification of cas no
The CAS Registry Mumber 14807-96-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,8,0 and 7 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 14807-96:
(7*1)+(6*4)+(5*8)+(4*0)+(3*7)+(2*9)+(1*6)=116
116 % 10 = 6
So 14807-96-6 is a valid CAS Registry Number.
InChI:InChI=1/3Mg.4O2Si.H2O.3O/c;;;4*1-3-2;;;;/h;;;;;;;1H2;;;/r3MgO.4O2Si.H2O/c3*1-2;4*1-3-2;/h;;;;;;;1H2
14807-96-6Relevant articles and documents
Changes to the triaxial composition of the hydrated phases (CaO/Al 2O3/SiO2) in the metakaolin/lime system
Garcia Gimenez, Rosario,Rodriguez, Olga,Vigil De La Villa, Raquel,Frias, Moises
, p. 1118 - 1122 (2012)
This study examines the composition of certain hydrates (calcium silicate, aluminum silicate, and related phases) produced by the pozzolanic reaction of waste-paper sludge that had previously been activated at different temperatures. It summarizes and compares the evolution of the oxide compounds, and records their stability intervals. Changes to their mineralogical composition were analyzed using X-Ray Diffraction, scanning electron microscopy, and energy dispersive X-ray spectroscopy. The hydration products from 1 to 360 days of curing time were CSH gels, hydrotalcite-type compounds (LDH), and stratlingite (C2ASH8). CSH gels were employed as substrates for growing other materials and their morphologies were modified from fibrous to hexagonal layers. The composition of the LDH-type compounds observed in the carbonate group varied with changes in curing time. Two LDH-type compound types were identified: (a) with and (b) without magnesium. Stratlingite was the only stable material after long-curing times.
REACTION OF MAGNESIUM HYDROXIDE WITH SOLUBLE SILICA UNDER HYDROTHERMAL CONDITIONS BELOW THE CRITICAL TEMPERATURE.
Muraishi
, p. 878 - 883 (1981)
The mechanism of the synthetic reaction of silicates under hydrothermal conditions is of interest, but it has not been investigated except for the syntheses of zeolite below 100 degree C. The purpose of this study is to gain some insight into the mechanis
Pharmaceutical composition comprising N-[2-(Diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene) methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
-
, (2010/01/07)
The present invention relates to a pharmaceutical composition comprising N-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1 H-pyrrole-3-carboxamide as active pharmaceutical ingredient.
Novel alpha-cyano-beta-oxopropionamides
-
, (2008/06/13)
α-(Substituted carbamoyl)-β-aryl- and heteroaryl-β-oxo-propionitriles of formula, , A-CO- enol ethers thereof and salts thereof, as well as pharmaceutical preparations containing same and methods of preparing and using these compounds are disclosed. Said compounds represent novel antiinflammatory and antirheumatic agents. Their property to interfere with both the cyclooxygenase and lipoxygenase pathway of the arachidonic fatty acid bioconversion to inflammatory mediators make them valuable therapeutics. These properties render the mentioned substituted carbamoyl-β-oxopropionitriles useful for the treatment of arthritic and rheumatic diseases and other inflammatory conditions in mammals.
