14774-37-9

Basic information

• Product Name: (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL
• Synonyms: (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL;(TETRAHYDRO-PYRAN-4-YL)-METHANOL;TETRAHYDROPYRAN-4-METHANOL;TERTAHYDROPYRAN-4-METHANOL;4-(Hydroxymethyl)tetrahydro-2H-pyran;4-(Hydroxymethyl)tetrahydropyr;(Tetrahydro-pyran-4-yl)-methanol ,97%;4-(Hydroxymethyl)tetrahydropyran
• CAS NO: 14774-37-9
• Molecular Formula: C₆H₁₂O₂
• Molecular Weight: 116.15828
• Product Categories: blocks;Heterocycles;Alcohols and Derivatives;Heterocycles series;Hydroxymethyl's;Pyrans, Piperidines &Piperazines;Pyrans, Piperidines & Piperazines
• Mol File: 14774-37-9.mol
• Article Data: 38

Chemical Properties

• Boiling Point: 105 °C
• Flash Point: 61°(142°F)
• Appearance: /
• Density: 1 g/cm³
• Vapor Pressure: 0.0259mmHg at 25°C
• Refractive Index: 1.4600
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.85±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL(14774-37-9)
• EPA Substance Registry System: (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL(14774-37-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22-41-37/38
• Safety Statements: 26-36/37/39-23-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 14774-37-9(Hazardous Substances Data)

Usage

Description

(Tetrahydro-2H-pyran-4-yl)methanol, also known as 4-(Hydroxymethyl)tetrahydropyran, is a colorless liquid with unique chemical properties that make it a versatile compound in various industries. It is characterized by its tetrahydropyran ring structure and hydroxymethyl group, which contribute to its reactivity and potential applications.

Uses

Used in Pharmaceutical Industry:
(Tetrahydro-2H-pyran-4-yl)methanol is used as a reagent for the identification and optimization of pteridinone Toll-like receptor 7 agonists. These agonists are crucial in the development of oral treatments for viral hepatitis, as they help modulate the immune response and combat the viral infection.
Used in Drug Synthesis:
(Tetrahydro-2H-pyran-4-yl)methanol serves as a starting material for the synthesis of [1-[(Tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone, a drug that acts as a CB2 cannabinoid receptor agonist. (Tetrahydro-2H-pyran-4-yl)methanol has potential therapeutic applications in various conditions, including pain management, inflammation, and neurodegenerative diseases.
Used in Chemical Research:
As a colorless liquid with unique chemical properties, (Tetrahydro-2H-pyran-4-yl)methanol is also utilized in chemical research for the development of new compounds and materials. Its reactivity and structural features make it a valuable building block in the synthesis of various organic molecules, contributing to advancements in material science and pharmaceutical chemistry.

InChI:InChI=1/C6H12O2/c7-5-6-1-3-8-4-2-6/h6-7H,1-5H2

Upstream product

• 25637-18-7 4-iodotetrahydropyran 
• 50-00-0 formaldehyd 
• 50675-18-8 3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde 
• 36838-71-8 4-methylene-tetrahydro-pyran 
• 280-64-8 9-bora-bicyclo[3.3.1]nonane 
• 130990-25-9 3-(2'-hydroxyethyl)tetrahydrofuran 
• 77-93-0 citric acid triethyl ester 
• 110238-91-0 tetrahydropyran-4-carboxylic acid methyl ester 
• 96835-17-5 ethyl tetrahydro-2H-pyran-4-carboxylate 
• 5337-03-1 tetrahydro-2H-pyran-4-carboxylic acid 

Downstream Products

• 101691-65-0 toluene-4-sulfonic acid tetrahydropyran-4-ylmethyl ester 
• 279-27-6 exo-1-azabicyclo[2.2.1]heptane 
• 5337-03-1 tetrahydro-2H-pyran-4-carboxylic acid 
• 1135035-14-1 3-(tetrahydro-2H-pyran-4-ylmethoxy)phenol 
• 1474110-21-8 N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide 
• 132291-95-3 4-(methanesulfonyloxymethyl)tetrahydropyran 

Relevant articles and documents

Radical hydroxymethylation of alkyl iodides using formaldehyde as a C1 synthon

Radical hydroxymethylation using formaldehyde as a C1 synthon is challenging due to the reversible and endothermic nature of the addition process. Here we report a strategy that couples alkyl iodide building blocks with formaldehyde through the use of photocatalysis and a phosphine additive. Halogen-atom transfer (XAT) from α-aminoalkyl radicals is leveraged to convert the iodide into the corresponding open-shell species, while its following addition to formaldehyde is rendered irreversible by trapping the transient O-radical with PPh3. This event delivers a phosphoranyl radical that re-generates the alkyl radical and provides the hydroxymethylated product.

VINYL COMPOUNDS AS FGFR AND VEGFR INHIBITORS

FGFR and VEGFR inhibitors are provided, and compounds represented by formula (1) or formula (II) as FGFR and VEGFR inhibitors, pharmaceutically acceptable salts or tautomers thereof are specifically disclosed.

Robust cobalt oxide catalysts for controllable hydrogenation of carboxylic acids to alcohols

The selective catalytic hydrogenation of carboxylic acids is an important process for alcohol production, while efficient heterogeneous catalyst systems are still being explored. Here, we report the selective hydrogenation of carboxylic acids using earth-abundant cobalt oxides through a reaction-controlled catalysis process. The further reaction of the alcohols is completely hindered by the presence of carboxylic acids in the reaction system. The partial reduction of cobalt oxides by hydrogen at designated temperatures can dramatically enhance the catalytic activity of pristine samples. A wide range of carboxylic acids with a variety of functional groups can be converted to the corresponding alcohols at a yield level applicable to large-scale production. Cobalt monoxide was established as the preferred active phase for the selective hydrogenation of carboxylic acids.