1477-42-5 Usage
Description
2-Amino-4-methylbenzothiazole is a white powder with off-white to slightly beige crystalline properties. It is an organic compound that belongs to the class of benzothiazoles, which are heterocyclic compounds with a wide range of applications in various industries.
Uses
Used in Chemical Synthesis:
2-Amino-4-methylbenzothiazole is used as a key intermediate in the synthesis of various organic compounds. It is particularly utilized in the synthesis of N-(4-methyl-1,3-benzothiazol-yl)-N-[(1,4,5,8-tetramethoxy-2-napthyl)methylidene]amine and Schiff's base via condensation with 2-acetonaphthone. This application is crucial in the development of new chemical entities with potential applications in various fields, such as pharmaceuticals, materials science, and agrochemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Amino-4-methylbenzothiazole is used as a building block for the development of novel therapeutic agents. Its unique chemical structure allows for the creation of new drugs with potential applications in treating various diseases and medical conditions.
Used in Materials Science:
2-Amino-4-methylbenzothiazole can also be employed in the field of materials science, where it can be used to develop new materials with specific properties. Its incorporation into polymers or other materials can lead to the creation of materials with enhanced performance characteristics, such as improved stability, reactivity, or conductivity.
Used in Agrochemicals:
In the agrochemical industry, 2-Amino-4-methylbenzothiazole can be used as a starting material for the synthesis of various agrochemicals, such as pesticides, herbicides, and fungicides. Its unique chemical properties make it a valuable component in the development of new and effective products for agricultural applications.
Air & Water Reactions
2-Amino-4-methylbenzothiazole is sensitive to moisture. Insoluble in water.
Reactivity Profile
An amine, organosulfide. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition 2-Amino-4-methylbenzothiazole emits very toxic fumes of SOx and NOx.
Fire Hazard
Flash point data for 2-Amino-4-methylbenzothiazole are not available. 2-Amino-4-methylbenzothiazole is probably combustible.
Check Digit Verification of cas no
The CAS Registry Mumber 1477-42-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,7 and 7 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1477-42:
(6*1)+(5*4)+(4*7)+(3*7)+(2*4)+(1*2)=85
85 % 10 = 5
So 1477-42-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H8N2S/c1-5-3-2-4-6-7(5)10-8(9)11-6/h2-4H,1H3,(H2,9,10)
1477-42-5Relevant articles and documents
Studies on phenothiazines. VII. (1). Synthesis of 3-substituted 2-aminobenzenethiols and their conversion into phenothiazines
Gupta,Ojha,Kumar
, p. 1325 - 1327 (1980)
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Method for synthesizing 4-methyl-2-benzothiazolehydrazine
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Paragraph 0048; 0057; 0059; 0061; 0063; 0065; 0067; 0069, (2020/07/12)
The invention discloses a method for synthesizing 4-methyl-2-benzothiazolehydrazine. The method comprises the following steps: carrying out synthesis reaction on o-toluidine and thiocyanate in acid toobtain o-tolylthiourea; carrying out a synthesis reaction on the o-tolylthiourea and a catalyst in water to obtain 2-amino-4-methylbenzothiazole; and carrying out a synthesis reaction on the 2-amino-4-methylbenzothiazole in hydrazine hydrate, so as to obtain the 4-methyl-2-benzothiazolehydrazine. The method for synthesizing the 4-methyl-2-benzothiazolehydrazine, provided by the invention, is simple to operate, less in three wastes, capable of repeatedly applying wastewater, high in product content, good in quality and suitable for industrial mass production.
SN-Donor methylthioanilines and copper(II) complexes: Synthesis, spectral properties, and in vitro antimicrobial activity
Olalekan, Temitope E.,Ogunlaja, Adeniyi S.,Watkins, Gareth M.
, (2019/04/25)
Methylthioanilines, a series of sulfur-nitrogen donor ligands substituted with OCH3, CH3, Cl, and Br, and their copper(II) complexes have been synthesized and characterized by 1H and 13C NMR, elemental analysis, FTIR, UV-Vis and EPR spectra, molar conductance, and magnetic susceptibility measurements. The NMR spectra of the ligands revealed that the para/ortho protons and para carbon were sensitive to the electronic effect of substituents. The CHNS analysis presented CuLCl2 (L = OCH3, CH3, Cl) and CuL2Cl2 (L = Br) stoichiometries for the copper complexes. FTIR spectra showed that the bidentate ligands were coordinated to the copper ion through their nitrogen and sulfur atoms. The electronic spectra have suggested square planar and octahedral geometries for these complexes. The EPR spectra demonstrated that the solid state copper(II) complexes possess dx2-y2 orbital ground state and g= > g > 2.0023 in a tetragonal environment. The compounds were evaluated for in vitro antimicrobial activity against S. aureus, B. subtilis, E. coli, and C. albicans. The copper complexes showed higher activity than the parent ligands against S. aureus and B. subtilis; the electron-donating OCH3 and CH3 derivatives were more active than the withdrawing Br- A nd Cl-substituted compounds.
Preparation method of 2-amino-4-methylbenzothiazole
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Paragraph 0060; 0062; 0063; 0074; 0084; 0096, (2018/10/19)
The invention relates to a preparation method of 2-amino-4-methylbenzothiazole. The preparation method comprises the steps of cyclization reaction, filtering and washing, recycling and the like. By the method, operation risks are reduced, the utilization rate of sulfuric acid is increased, zero emission of gas is realized basically, the emission amount of waste water is reduced effectively, and thus, the yield of synthesis is stable.
