145127-37-3

Basic information

• Product Name: Methyl 3-morpholin-4-yl-benzoate
• Synonyms: Methyl 3-morpholin-4-yl-benzoate;3-(4-morpholinyl)Benzoic acid ethyl ester;Ethyl 3-morpholinobenzoate
• CAS NO: 145127-37-3
• Molecular Formula: C₁₃H₁₇NO₃
• Molecular Weight: 235.28
• Product Categories: pharmacetical
• Mol File: 145127-37-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 371.9°Cat760mmHg
• Flash Point: 178.7°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 9.98E-06mmHg at 25°C
• Refractive Index: 1.54
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 3-morpholin-4-yl-benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-morpholin-4-yl-benzoate(145127-37-3)
• EPA Substance Registry System: Methyl 3-morpholin-4-yl-benzoate(145127-37-3)

Safety Data

• Hazardous Substances Data: 145127-37-3(Hazardous Substances Data)

Usage

General Description

Methyl 3-morpholin-4-yl-benzoate is a chemical compound with the molecular formula C13H15NO4. It is a colorless to pale yellow liquid with a faint odor. Methyl 3-morpholin-4-yl-benzoate is commonly used as an intermediate in the production of pharmaceuticals and other organic compounds. It is also used as a solvent in various chemical reactions and processes. Methyl 3-morpholin-4-yl-benzoate is considered to be relatively stable under normal conditions, but it should be handled and stored with care to avoid any potential hazards or risks. Overall, this chemical compound has diverse applications in the pharmaceutical and chemical industries due to its versatility and stability.

InChI:InChI=1/C12H15NO3/c1-15-12(14)10-3-2-4-11(9-10)13-5-7-16-8-6-13/h2-4,9H,5-8H2,1H3

Upstream product

• 110-91-8 morpholine 
• 33668-25-6 ethyl 3-oxocyclohexanecarboxylate 
• 58313-23-8 3-iodobenzoic acid methyl ester 
• 451-02-5 ethyl 3-fluorobenzoate 
• 24398-88-7 ethyl 3-bromobenzoate 

Downstream Products

• 215309-00-5 3-(4-morpholinyl)benzoic acid 

Relevant articles and documents

Electrochemical Cross-Dehydrogenative Aromatization Protocol for the Synthesis of Aromatic Amines

The introduction of amines onto aromatics without metal catalysts and chemical oxidants is synthetically challenging. Herein, we report the first example of an electrochemical cross-dehydrogenative aromatization (ECDA) reaction of saturated cyclohexanones and amines to construct anilines without additional metal catalysts and chemical oxidants. This reaction exhibits a broad scope of cyclohexanones including heterocyclic ketones, affording a variety of aromatic amines with various functionalities, and shows great potential in the synthesis of biologically active compounds.

Metal-free Synthesis of Aryl Amines: Beyond Nucleophilic Aromatic Substitution

A mild and metal-free approach to C?N coupling is described that employs diaryliodonium salt electrophiles and secondary aliphatic amine nucleophiles. This reaction results in direct ipso-substitution of the iodonium moiety and unsymmetrical aryl(TMP)iodonium salts are primarily employed. Moreover, arene substituents and substitution patterns that currently pose a challenge to classical metal-free methods are accommodated and the alicyclic amine nucleophiles used here are unprecedented in other contemporary metal-free C?N coupling reactions.

Synthesis of meta-substituted aniline derivatives by nucleophilic substitution

Substitution by amines of fluorobenzenes containing a meta- substituted electron withdrawing group (EWG), in DMSO at 100 °C over 60 h gave meta-substituted aniline derivatives in isolated yields of up to 98%. The scope of the reaction is explored in terms of reaction conditions and substrates. It is postulated that facile meta-substitutions are facilitated through field stabilisation of the intermediate anion by EWG substituents.