144676-94-8Relevant articles and documents
Methylenebisphosphonic acid derivatives
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, (2008/06/13)
Novel pharmacologically active methylenebisphosphonates having formula (I) wherein R1 -R4 independently are C1 -C10 -alkyl, C3 -C10 -cycloalkyl, aryl, aralkyl, silyl SiR3 or hydrogen, whereby in formula (I) at least one of the groups R1 -R4 is hydrogen and at least one of the groups R1 -R4 is different from hydrogen, Q1 is hydrogen, hydroxyl, halogen, amino NH2, or OR'1, wherein R'1 is C1 -C4 -alkyl or acyl, Q2 is the group (α) wherein Y is a six-membered heterocyclic group, or a carbocyclic aromatic group, X is a bond, O, S or NR'", wherein R'" is hydrogen, lower alkyl, or acyl, n is the integer 0 to 6, and R' and R" are hydrogen or lower alkyl provided that as a ring atom of the ring Y and/or a chain atom of the group X, there is always at least one heteroatom from the group O, N and S, including the steroisomers and the salts of the compounds.