1445684-99-0 Usage
Description
4-Chloro-2-bromotoluene is an organic compound with the molecular formula C7H6BrCl. It is a derivative of toluene, featuring a chlorine atom at the 4th position and a bromine atom at the 2nd position on the benzene ring. 4-Chluoro-2-bromotoluene is known for its chemical properties and potential applications in various industries.
Uses
Used in Pharmaceutical Research:
4-Chloro-2-bromotoluene is used as an intermediate in pharmaceutical research for the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a valuable building block in the development of new drugs and medications.
Used in Chemical Synthesis:
In the chemical industry, 4-Chloro-2-bromotoluene is used as a starting material for the synthesis of various organic compounds. Its reactive chlorine and bromine atoms make it a versatile compound for further chemical reactions, leading to the production of a wide range of products.
Used in Dye and Pigment Production:
4-Chloro-2-bromotoluene is also utilized in the production of dyes and pigments due to its ability to form colored compounds. Its chemical properties make it suitable for creating a variety of colors used in different applications, such as in the textile, paint, and plastics industries.
Used in Agrochemicals:
In the agrochemical industry, 4-Chloro-2-bromotoluene is employed as a precursor for the synthesis of various agrochemicals, including pesticides and herbicides. Its chemical structure contributes to the development of effective compounds that help protect crops and enhance agricultural productivity.
Synthesis
To
a
solution
of
3-aminobenzenethiol
(4.43
g,
35.4
mmol)
in
THF
(225
mL)
was
added
sodium
hydride
(1.77
g,
44.3
mmol)
at
0
°C
and
stirred
for
30
min.
Then,
2,2,2-trifluoroethyl
4-
methylbenzenesulfonate
(9.0
g,
35.4
mmol)
was
added
and
the
reaction
mixture
was
stirred
for
18
h.
The
reaction
mixture
was
quenched
with
water
(20
mL)
and
extracted
with
EtOAc
(2x50
mL).
The
combined
organic
extracts
were
washed
with
water,
dried
over
Na2SO4,
fdtered,
and
concentrated
under
reduced
pressure.
The
crude
residue
was
purified
by
flash
chromatography
through
a
Redi-Sep
pre-packed
silica
gel
column,
eluting
with
a
gradient
of
5
%
to
10
%
EtOAc
in
hexanes,
to
give
3-((2,2,2-
trifluoroethyl)thio)aniline
(5
g,
68
%
yield)
as
a
pale
brown
oil.
Check Digit Verification of cas no
The CAS Registry Mumber 1445684-99-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,5,6,8 and 4 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1445684-99:
(9*1)+(8*4)+(7*4)+(6*5)+(5*6)+(4*8)+(3*4)+(2*9)+(1*9)=200
200 % 10 = 0
So 1445684-99-0 is a valid CAS Registry Number.
1445684-99-0Relevant articles and documents
KIF18A INHIBITORS
-
Paragraph 0189; 0265; 0267, (2021/02/12)
Compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.
SUBSTITUTED PHENYLPIPERAZINE COMPOUND AND PEST CONTROL AGENT
-
Paragraph 0558; 0559, (2016/10/09)
PROBLEM TO BE SOLVED: To provide a pest control agent for controlling harmful organisms in agricultural and horticultural fields or harmful organisms to an animal such as a pet and a domestic animal or a domestic animal. SOLUTION: There is provided a substituted phenyl-piperazine compound represented by the following formula (1) or a salt thereof. (wherein, A represents an alkyl group having 1 to 20 carbon atoms which may be substituted or the like; R represents an alkyl group having 1 to 20 carbon atoms which may be substituted or the like; X represents an alkyl having 1 to 6 carbon atoms which may be substituted with a halogen atom, a cyano group or the like; Y represents a halogen atom and an alkyl group having 1 to 6 carbon atoms which may be substituted; m represents any one of integers of 0 to 4; n represents any one of integers of 0 to 8; p represents any one of integers of 0 to 2; and q and r represent any one of integers of 0 to 1.) COPYRIGHT: (C)2015,JPO&INPIT
