1443257-13-3

Basic information

• Product Name: (3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetic acid methyl ester
• Synonyms: (3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetic acid methyl ester
• CAS NO: 1443257-13-3
• Molecular Weight: 329.306
• Mol File: 1443257-13-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetic acid methyl ester(1443257-13-3)
• EPA Substance Registry System: (3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetic acid methyl ester(1443257-13-3)

Safety Data

• Hazardous Substances Data: 1443257-13-3(Hazardous Substances Data)

Upstream product

• 1038410-94-4 3,5-bis-(4-fluoro-phenyl)-1H-(1,2,4)triazole 
• 96-32-2 bromoacetic acid methyl ester 
• 2339-59-5 4-fluorobenzamidine 
• 1194-02-1 4-fluorobenzonitrile 

Downstream Products

• 1443257-71-3 (3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl chloride 
• 1443257-74-6 2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4) triazol-1-yl)-1-piperazin-1-yl-ethanone 
• 1443257-75-7 4-(2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 1443253-91-5 4-(2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl)-1-pyridin-2-yl-piperazin-2-one 
• 1443253-94-8 1-(4-benzo[d]isoxazol-3-yl-piperidin-1-yl)-2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-ethanone 
• 1443254-82-7 1-(2-amino-4,5,7,8-tetrahydro-thiazolo[4,5-d]azepin-6-yl)-2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-ethanone 
• 1443256-55-0 2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-[4-(5,6-dihydro-4H-(1,3) thiazin-2-yl)-piperazin-1-yl]-ethanone 
• 1447725-99-6 2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(4-ethoxy-pyridin-2-yl)-piperazin-1-yl)-ethanone 
• 1447724-11-9 2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(5-methoxy-pyrimidin-2-yl)-piperazin-1-yl)-ethanone 
• 1447723-84-3 2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(4-methoxy-pyridin-2-yl)-piperazin-1-yl)-ethanone 
• 1443257-42-8 (3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetic acid 
• 1447723-56-9 2-(4-(2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl)-piperazin-1-yl)-nicotinonitrile 

Relevant articles and documents

NOVEL COMPOUNDS

This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, X, R1, R2, R3 have meanings given in the description.

SUBSTITUTED TRIAZOLES AND THEIR USE FOR TREATMENT AND/OR PREVENTION NEUROLOGICAL AND PSYCHIATRIC DISORDERS

This invention relates to compounds of formula (I), their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, Ar, R1, R2, R3 have meanings given in the description.