1440523-97-6

Basic information

• Product Name: N-(3-phenylpropyl)-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
• Synonyms: N-(3-phenylpropyl)-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
• CAS NO: 1440523-97-6
• Molecular Weight: 352.907
• Mol File: 1440523-97-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-phenylpropyl)-1,2,3,4-tetrahydroacridin-9-amine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-phenylpropyl)-1,2,3,4-tetrahydroacridin-9-amine hydrochloride(1440523-97-6)
• EPA Substance Registry System: N-(3-phenylpropyl)-1,2,3,4-tetrahydroacridin-9-amine hydrochloride(1440523-97-6)

Safety Data

• Hazardous Substances Data: 1440523-97-6(Hazardous Substances Data)

Upstream product

• 637-59-2 1-Bromo-3-phenylpropane 
• 1684-40-8 tacrine monohydrochloride 

Relevant articles and documents

Comparison of novel tacrine and 7-MEOTA derivatives with aromatic and alicyclic residues: Synthesis, biological evaluation and docking studies

Cholinesterase inhibitors play an essential role in the treatment of Alzheimer's disease. Since their first introduction over a decade ago, they are an indispensable part of Alzheimer's disease therapy and remain at the forefront of scientific interest worldwide. In this manuscript new analogs of THA and 7-MEOTA were designed, synthesized, and evaluated for their inhibitory activity against both acetylcholinesterase and butyrylcholinesterase. Cholinergic properties were investigated and quantified with respect to their side chain residues (aromatic or alicyclic). All synthesized compounds proved to have potent inhibitory activity at micromolar range. Moreover, compound 4 demonstrated promising efficacy and appears to be an ideal candidate for further testing.