144-49-0 Usage
Chemical Properties
Different sources of media describe the Chemical Properties of 144-49-0 differently. You can refer to the following data:
1. Colorless crystal.
Soluble in water and alcohol.
2. Fluoroacetic acid is a colorless crystalline
solid.
Uses
Different sources of media describe the Uses of 144-49-0 differently. You can refer to the following data:
1. Fluoroacetic acid (CH2FCOOH) is very poisonous. It is used to kill rats and mice.
2. Rodenticide.
Definition
ChEBI: A haloacetic acid that is acetic acid in which one of the methyl hydrogens is substituted by fluorine.
General Description
A colorless crystalline solid. May be toxic by ingestion. Used to make other chemicals.
Air & Water Reactions
Water soluble.
Reactivity Profile
Fluoroacetic acid is a halogenated carboxylic acid derivative. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Fluoroacetic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.
Hazard
Toxic by ingestion.
Health Hazard
Fluoroacetic acid is very toxic; ingestion of small quantities may cause death.
Fire Hazard
When heated to decomposition, Fluoroacetic acid emits highly toxic fumes of fluorine containing compounds. Some of these materials may burn but none ignite readily. These materials may ignite combustibles (wood, paper, oil, etc.).
Safety Profile
Poison by ingestion,
subcutaneous, intraperitoneal, and intravenous routes. Affects the human
central nervous system, causing convulsions
and ventricular fibrdlation. When heated to
decomposition it emits toxic fumes of F and Na2O. See also SODIUM
FLUOROACETATE.
Potential Exposure
This material is used as a rodenticide
and a drug.
Shipping
UN2642 Fluoroacetic acid, Hazard Class: 6.1;
Labels: 6.1-Poisonous materials.
Incompatibilities
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explo sions. Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides. Reacts with reducing
agents releasing flammable gas.
Waste Disposal
Use a licensed professional
waste disposal service to dispose of this material. Dissolve
or mix the material with a combustible solvent and burn in
a chemical incinerator equipped with an afterburner and
scrubber. All federal, state, and local environmental regula tions must be observed.
Check Digit Verification of cas no
The CAS Registry Mumber 144-49-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 4 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 144-49:
(5*1)+(4*4)+(3*4)+(2*4)+(1*9)=50
50 % 10 = 0
So 144-49-0 is a valid CAS Registry Number.
InChI:InChI=1/C2H3FO2/c3-1-2(4)5/h1H2,(H,4,5)
144-49-0Relevant articles and documents
Organocatalytic Enantioselective Synthesis of α-Fluoro-β-amino Acid Derivatives
Straub, Matthew R.,Birman, Vladimir B.
, p. 7550 - 7553 (2018)
Asymmetric cyclocondensation of N-sulfonylimines with fluoroacetic acid promoted by isothiourea catalyst HBTM-2 generates 3-fluoro-β-lactams with high enantio- and diastereoselectivity. These reactive compounds are opened with alcohols or amines to produce the corresponding α-fluoro-β-amino acid derivatives in moderate yields.
Grakauskas,V.
, p. 963 - 965 (1969)
Hapten design and monoclonal antibody to fluoroacetamide, a small and highly toxic chemical
Yang, Ling,Zhang, Xiya,Shen, Dongshuai,Yu, Xuezhi,Li, Yuan,Wen, Kai,Shen, Jianzhong,Wang, Zhanhui
, p. 1 - 12 (2020/07/08)
Fluoroacetamide (FAM) is a small (77 Da) and highly toxic chemical, formerly used as a rodenticide and potentially as a poison by terrorists. Poisoning with FAM has occurred in humans, but few reliably rapid detection methods and antidotes have been reported. Therefore, producing a specific antibody to FAM is not only critical for the development of a fast diagnostic but also a potential treatment. However, achieving this goal is a great challenge, mainly due to the very low molecular weight of FAM. Here, we design two groups of FAM haptens for the first time, maximally exposing the fluorine or amino groups, with the aid of linear aliphatic or phenyl-contained spacer arms. Interestingly, whereas the hapten with fluorine at the far end of the hapten did not induce an antibody response to FAM, the hapten with an amino group at the far end and phenyl-contained spacer arm triggered a significantly specific antibody response. Finally, a monoclonal antibody (mAb) named 5D11 was successfully obtained with an IC50 value of 97 μg mL?1 and negligible cross-reactivities to the other nine functional and structural analogs.
Nucleofugality of aliphatic carboxylates in mixtures of aprotic solvents and water
Mati, Mirela,Denegri, Bernard,Kronja, Olga
, p. 375 - 384 (2015/10/12)
The leaving group ability (nucleofugality) of fluoroacetate, chloroacetate, bromoacetate, dichloroacetate, trifluoroacetate, trichloroacetate, heptafluorobutyrate, formate, isobutyrate, and pivalate have been derived from the solvolysis rate constants of the corresponding X,Y-substituted benzhydryl carboxylates in 60 % and 80 % aqueous acetonitrile and 60 % aqueous acetone, applying the LFER equation: log k = sf(Ef + Nf). The experimental barriers (ΔG?,exp) for solvolyses of 11 reference dianisylmethyl carboxylates in these solvents correlate very well (r = 0.994 in all solvents) with ΔG?,model of the model σ-assisted heterolytic displacement reaction of cis-2,3-dihydroxycyclopropyl trans-carboxylates calculated earlier. Linear correlation observed between the log k for the reference dianisylmethyl carboxylates and the sf values enables estimation of the reaction constant (sfestim). Using the ΔG?,exp vs. ΔG?,model correlation, and taking the estimated sfestim, the nucleofugality parameters for other 34 aliphatic carboxylates have been determined in 60 % and 80 % aqueous acetonitrile and 60 % aqueous acetone. The most important variable that determines the reactivity of aliphatic carboxylates in aprotic solvent/water mixtures is the inductive effect of the group(s) attached onto the carboxylate moiety.
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