143562-54-3Relevant articles and documents
Elemental fluorine. Part 7. New oxidation methodology
Chambers, Richard D.,Hutchinson, John,Sandford, Graham,Shah, Aneela,Vaughan, Julian F. S.
, p. 15833 - 15842 (1997)
Reaction of fluorine with water in the presence of acids provides new oxidants for 'in-situ' oxidation of ketones. Direct reaction of fluorine with anhydrous alcohols and 1,2-diols provides simple methodology for oxidation to corresponding secondary ketones or α-hydroxy ketones.
Cobalt-Catalyzed Aerobic Oxidative Cleavage of Alkyl Aldehydes: Synthesis of Ketones, Esters, Amides, and α-Ketoamides
Li, Tingting,Hammond, Gerald B.,Xu, Bo
supporting information, p. 9737 - 9741 (2021/05/31)
A widely applicable approach was developed to synthesize ketones, esters, amides via the oxidative C?C bond cleavage of readily available alkyl aldehydes. Green and abundant molecular oxygen (O2) was used as the oxidant, and base metals (cobalt and copper) were used as the catalysts. This strategy can be extended to the one-pot synthesis of ketones from primary alcohols and α-ketoamides from aldehydes.
Tetrahydropyranone preparation method
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Paragraph 0017; 0022, (2018/10/11)
The invention relates to a tetrahydropyranone preparation method, the method takes acetone and diethyl oxalate as raw materials, through steps of a ring closure reaction, a decarboxylation reaction, and a reduction reaction, three-step high-yield synthesis is realized to obtain tetrahydropyranone. The tetrahydropyranone preparation method has the advantages of high yield, low cost, and easy operation, and is suitable for industrial preparation method.
Synthesis of azasilacyclopentenes and silanols: Via Huisgen cycloaddition-initiated C-H bond insertion cascades
Shih, Jiun-Le,Jansone-Popova, Santa,Huynh, Christopher,May, Jeremy A.
, p. 7132 - 7137 (2017/10/05)
An unusual transition metal-free cascade reaction of alkynyl carbonazidates was discovered to form azasilacyclopentenes. Mild thermolysis afforded the products via a series of cyclizations, rearrangements, and an α-silyl C-H bond insertion (rather than the more common Wolff rearrangement, 1,2-shift, or β-silyl C-H insertion) to form silacyclopropanes. A mechanistic proposal for the sequence was informed by control experiments and the characterization of reaction intermediates. The substrate scope and post-cascade transformations were also explored.