143142-90-9 Usage
Description
R-(+)-2-TRIFLUOROMETHYLOXIRANE, 97, also known as (R)-(+)-3,3,3-Trifluoro-1,2-epoxypropane, is a chemical compound with a trifluoromethyl group and an epoxide ring. It is a versatile building block in the synthesis of various pharmaceutical compounds and has potential applications in the development of new drugs.
Uses
Used in Pharmaceutical Industry:
R-(+)-2-TRIFLUOROMETHYLOXIRANE, 97 is used as a substrate for the synthesis of substituted trifluoro amino propanols, which are potent inhibitors of cholesteryl ester transfer protein. These inhibitors play a crucial role in managing cholesterol levels and can be used in the treatment of cardiovascular diseases.
Used in Chiral Synthesis:
R-(+)-2-TRIFLUOROMETHYLOXIRANE, 97 is used as a starting material for the preparation of (2R) Trifluoro-(methoxybenzyloxy)-propanol (chiral glycol) by reacting with 4-methoxybenzyl alcohol in the presence of NaH. This chiral glycol intermediate is further utilized in the synthesis of trifluoromethyl glycol carbamates, which have potential as monoacylglycerol lipase (MAGL) inhibitors. MAGL inhibitors can be used in the treatment of various conditions, including pain, inflammation, and neurodegenerative diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 143142-90-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,1,4 and 2 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 143142-90:
(8*1)+(7*4)+(6*3)+(5*1)+(4*4)+(3*2)+(2*9)+(1*0)=99
99 % 10 = 9
So 143142-90-9 is a valid CAS Registry Number.
InChI:InChI=1/C3H3F3O/c4-3(5,6)2-1-7-2/h2H,1H2/t2-/m1/s1
143142-90-9Relevant articles and documents
COMPOUNDS AND THEIR METHODS OF USE
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Paragraph 0243; 0244, (2020/12/13)
The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.
Method for Industrial Production of Optically Active Fluoroalkyl Ethylene Oxide
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Paragraph 0139; 0140, (2018/11/21)
It is possible to produce an optically active fluoroalkyl chloromethyl alcohol with a high optical purity and a good yield by treating a fluoroalkyl chloromethyl ketone with a microorganism having an activity for asymmetrically reducing the ketone or an enzyme having the activity. Then, it is possible to obtain a fluoroalkyl ethylene oxide by treating the alcohol with a base. Industrial implementation of the production method of the present invention is easy.
OXYSTEROLS AND METHODS OF USE THEREOF
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Paragraph 00353; 00355; 00705, (2018/05/16)
Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R2, R3, R4, R5, and and R6 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.