1429651-50-2

Basic information

• Product Name: HPOB
• Synonyms: HPOB;N-hydroxy-4-(2-((2-hydroxyethyl)(phenyl)amino)-2-oxoethyl)benzamide;4-[(hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl- benzeneacetamide HPOB;4-[(Hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl-benzeneacetamide
• CAS NO: 1429651-50-2
• Molecular Formula: C₁₇H₁₈N₂O₄
• Molecular Weight: 314.33582
• Product Categories: Inhibitors
• Mol File: 1429651-50-2.mol
• Article Data: 1

Chemical Properties

• Appearance: white to beige/
• Storage Temp.: 2-8°C
• Solubility: DMSO: soluble1mg/mL, clear (warmed)
• CAS DataBase Reference: HPOB(CAS DataBase Reference)
• NIST Chemistry Reference: HPOB(1429651-50-2)
• EPA Substance Registry System: HPOB(1429651-50-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1429651-50-2(Hazardous Substances Data)

Usage

Uses

HPOB is a histone deacetylase 6 inhibitor used in the enhancement of anti-cancer drugs.

Upstream product

• 227805-38-1 N-(2-((tert-butyldimethylsilyl)oxy)ethyl)aniline 
• 62-53-3 aniline 
• 122-98-5 2-Anilinoethanol 
• 73401-74-8 4-hydroxymethylphenylacetic acid 
• 1429653-16-6 4-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)-N-hydroxybenzamide 
• 22744-12-3 [4-(methoxycarbonyl)phenyl]acetic acid 
• 1429653-12-2 methyl 4-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)benzoate 

Relevant articles and documents

NOVEL MOLECULES THAT SELECTIVELY INHIBIT HISTONE DEACETYLASE 6 RELATIVE TO HISTONE DEACETYLASE 1

The compounds of the present invention are HDAC6 selective inhibitors which are identified on the basis of accumulation of acetylated tubulin without accumulation of acetylated histones. Histone deacetylase or "HDAC" refers to enzymes capable of cleaving an acetyl group (-C(=0)CH3) from proteins, including histone and microtubulins. Compositions comprising the molecules and methods for their use to inhibit the activity of histone deacetylase, including for treatment, are also disclosed.