14254-41-2 Usage
Description
Bis(2,4-dichlorophenyl) chlorophosphate is a white solid that serves as a phosphate catalyst and a coupling agent in various chemical reactions. It is known for its ability to facilitate the direct conversion of alcohols to azides through activation and is also utilized in the synthesis of oligonucleotide phosphorodithioates.
Uses
Used in Chemical Synthesis:
Bis(2,4-dichlorophenyl) chlorophosphate is used as a phosphate catalyst for the direct conversion of alcohols to azides via activation. This application is significant in the field of chemical synthesis, as it allows for the efficient production of azides, which are important intermediates in the synthesis of various organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Bis(2,4-dichlorophenyl) chlorophosphate is used as a coupling agent in the synthesis of oligonucleotide phosphorodithioates. These oligonucleotides are essential components in the development of new drugs and therapies, particularly in the field of genetic research and gene therapy.
Used in Research and Development:
Bis(2,4-dichlorophenyl) chlorophosphate is also employed in research and development laboratories, where it is used to study the mechanisms of phosphate catalysis and the synthesis of various chemical compounds. Its versatility as a catalyst and coupling agent makes it a valuable tool for scientists working on the development of new chemical processes and products.
Check Digit Verification of cas no
The CAS Registry Mumber 14254-41-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,2,5 and 4 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 14254-41:
(7*1)+(6*4)+(5*2)+(4*5)+(3*4)+(2*4)+(1*1)=82
82 % 10 = 2
So 14254-41-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H6Cl5O3P/c13-7-1-3-11(9(15)5-7)19-21(17,18)20-12-4-2-8(14)6-10(12)16/h1-6H
14254-41-2Relevant articles and documents
A highly enantioselective synthesis of phosphate triesters
Nakayama, Kensaku,Thompson, Wayne J.
, p. 6936 - 6942 (2007/10/02)
A general methodology for the preparation of both enantiomers of a variety of trialkyl phosphates with enantiomeric excesses ranging from 87 to 92% is described. Bis(2,4-dichlorophenyl) phosphoramidates bearing a 2-substituted pyrrolidine moiety as the chiral auxiliary are prepared and examined for their stereoselectivity. Considerations based on both the absolute configuration of the product phosphates as well as the X-ray structural determination of one of the bis(2,4-dichlorophenyl) phosphoramidates suggest these substitutions occur with preponderant inversion of configuration at phosphorus.
