1425038-21-6 Usage
Description
(S)-3,3-Dimethyl-2-((1R,2R)-2-pent-4-ynyl-cyclopropoxycarbonylamino)-butyric acid, tert-butylamine salt is a complex organic compound with a specific stereochemistry. It is characterized by its unique molecular structure, which includes a cyclopropane ring, a pent-4-yn-1-yl group, and a tert-butylamine salt moiety. (S)-3,3-Dimethyl-2-((1R,2R)-2-pent-4-ynyl-cyclopropoxycarbonylamino)-butyric acid, tert-butylamine salt is known for its antiviral properties and is used as an intermediate in the synthesis of Grazoprevir (M424985), a second-generation NS3/4A protease inhibitor.
Uses
Used in Pharmaceutical Industry:
(S)-3,3-Dimethyl-2-((1R,2R)-2-pent-4-ynyl-cyclopropoxycarbonylamino)-butyric acid, tert-butylamine salt is used as an intermediate in the synthesis of Grazoprevir, a second-generation NS3/4A protease inhibitor. It plays a crucial role in the development of antiviral medications, particularly those targeting COVID-19.
Used in Antiviral Applications:
(S)-3,3-Dimethyl-2-((1R,2R)-2-pent-4-ynyl-cyclopropoxycarbonylamino)-butyric acid, tert-butylamine salt is used as an antiviral agent, specifically in the development of Grazoprevir, which is a second-generation NS3/4A protease inhibitor. It is involved in COVID-19-related research, aiming to provide effective treatment options for the virus by inhibiting the replication of the virus within host cells.
Used in Research and Development:
(S)-3,3-Dimethyl-2-((1R,2R)-2-pent-4-ynyl-cyclopropoxycarbonylamino)-butyric acid, tert-butylamine salt is also utilized in research and development for the creation of new antiviral drugs and therapies. Its unique structure and properties make it a valuable compound for exploring novel approaches to combat viral infections, including COVID-19.
Check Digit Verification of cas no
The CAS Registry Mumber 1425038-21-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,5,0,3 and 8 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1425038-21:
(9*1)+(8*4)+(7*2)+(6*5)+(5*0)+(4*3)+(3*8)+(2*2)+(1*1)=126
126 % 10 = 6
So 1425038-21-6 is a valid CAS Registry Number.
1425038-21-6Relevant articles and documents
Asymmetric Synthesis of Functionalized trans-Cyclopropoxy Building Block for Grazoprevir
Xu, Feng,Zhong, Yong-Li,Li, Hongming,Qi, Ji,Desmond, Richard,Song, Zhiguo J.,Park, Jeonghan,Wang, Tao,Truppo, Matthew,Humphrey, Guy R.,Ruck, Rebecca T.
supporting information, p. 5880 - 5883 (2017/11/10)
A practical and asymmetric synthesis of a functionalized trans-cyclopropoxy building block for the preparation of the HCV NS3/4a protease inhibitor grazoprevir is reported. Intramolecular SN2 displacement-ring closure, followed by a Baeyer-Villiger oxidation, yields the desired trans-cyclopropanol with full control of diastereoselectivity. A terminal alkyne is then effectively installed using LiNH(CH2)2NEt2. Starting from (S)-epichlorohydrin, the cyclopropoxy building block is prepared in 51% overall yield with >99.8% optical purity without isolation of any intermediates.